In this study, we designed an artificial pathway composed of tyramine β-hydroxylase (TBH)
and phenylethanolamine N-methyltransferase (PNMT) for the biosynthesis of both …

Tropone is a seven-membered ring nonbenzenoid aromatic compound. It is the core
structure of tropolonoids, which have various biological activities. In this study, a hybrid …

Phenylalkylamines, such as the plant compounds ephedrine and pseudoephedrine and the
animal neurotransmitters dopamine and adrenaline, compose a large class of natural and …

Tropine and pseudotropine with opposite stereospecific configurations as platform
compounds are central building blocks in both biosynthesis and chemical synthesis of …

Tropane alkaloids (TAs) are a class of phytochemicals produced by plants of the nightshade
family used for treating diverse neurological disorders. Here, we demonstrate de novo …

Protocatechuic acid (PCA) is an important drug intermediate with antibacterial and
antioxidant properties. In this study, the whole-cell bioconversion of l-tyrosine into PCA was …

N-acetyltyramine as a tyramine alkaloid has drawn great attention because of its excellent
anti-free radical, antithrombotic, and antitumour activity. Therefore, it is an attractive …

5-Hydroxytryptophan (5-HTP) is a drug that is clinically effective against depression,
insomnia, obesity, chronic headaches, etc. It is only commercially produced by the extraction …

Background The demand for melatonin is increasing due to its health-promoting bioactivities
such as antioxidant and sleep benefits. Although melatonin is present in various organisms …

Tyramine, the decarboxylated product of tyrosine by catalysis via the tyrosine decarboxylase
enzyme (TYDC), is employed as an acyl acceptor in the synthesis of hydroxycinnamic acid …