Differences in SARS-CoV-2-specific immune responses have been observed between
individuals following natural infection or vaccination. In addition to already known factors …

Development of adaptive immunity after COVID-19 and after vaccination against SARS-CoV-
2 is predicated on recognition of viral peptides, presented on HLA class II molecules, by …

This article provides a review of studies evaluating the role of host (and viral) genetics
(including variation in HLA genes) in the immune response to coronaviruses, as well as the …

The conditions and extent of cross‐protective immunity between severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) and common‐cold human coronaviruses (HCoVs) …

Highlights•Variation in both HLA and SARS-CoV-2 impact antigen presentation to T
cells.•HLA variation influences COVID-19 outcomes and T-cell responses to SARS-CoV …

SARS‐CoV‐2 infection results in different outcomes ranging from asymptomatic infection to
mild or severe disease and death. Reasons for this diversity of outcome include differences …

HLA molecules are key restrictive elements to present intracellular antigens at the
crossroads of an effective T-cell response against SARS-CoV-2. To determine the impact of …

The worldwide coronavirus disease 2019 pandemic was sparked by the severe acute
respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) that first surfaced in …

The rapid, global spread of the SARS-CoV-2 virus during the current pandemic has
triggered numerous efforts in clinical and research settings to better understand the host …

Elucidating antiviral CD8 T lymphocyte responses to SARS-CoV-2 may shed light on the
heterogeneity of clinical outcomes and inform vaccine or therapeutic approaches. To …