Absence of BRAF, NRAS, KRAS, HRAS Mutations, and RET/PTC Gene Rearrangements Distinguishes Dominant Nodules in Hashimoto Thyroiditis from …

PM Sadow, MC Heinrich, CL Corless, JA Fletcher… - Endocrine …, 2010 - Springer
Dominant nodules within Hashimoto thyroiditis (HT) may present with unique morphological
features that overlap with but are not diagnostic of papillary thyroid carcinoma (PTC) …

Analysis of BRAF point mutation and RET/PTC rearrangement refines the fine-needle aspiration diagnosis of papillary thyroid carcinoma

G Salvatore, R Giannini, P Faviana… - The Journal of …, 2004 - academic.oup.com
Point mutations in BRAF are genetic hallmarks of papillary thyroid carcinoma (PTC). In this
retrospective study, we examined thyroid aspirates and corresponding paraffin-embedded …

Prevalence of RET/PTC rearrangements in Hashimoto's thyroiditis and papillary thyroid carcinomas

MN Nikiforova, CM Caudill… - … Journal of Surgical …, 2002 - journals.sagepub.com
The relationship between Hashimoto's thyroiditis (HT) and follicular cell-derived thy roid
cancer remains unclear. Recently, 2 studies reported a 95% prevalence of RET/PTC …

Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas

AJ Adeniran, Z Zhu, M Gandhi… - The American journal …, 2006 - journals.lww.com
Papillary carcinoma is the most common type of thyroid malignancy. It has been recently
shown that these tumors commonly have one of three genetic alterations: BRAF point …

Hashimoto's thyroiditis shares features with early papillary thyroid carcinoma

S Arif, A Blanes, SJ Diaz‐Cano - Histopathology, 2002 - Wiley Online Library
Neoplastic transformation is a multistep process that results in a continuous spectrum from
the normal (physiological) state to a fully established neoplasm. The gold standard for …

BRAF mutation positive papillary thyroid carcinoma is less advanced when Hashimoto's thyroiditis lymphocytic infiltration is present

V Marotta, A Guerra, MC Zatelli, ED Uberti… - Clinical …, 2013 - Wiley Online Library
Background Concomitant papillary thyroid cancer (PTC) and H ashimoto's thyroiditis (HT) is
a frequent occurrence. Whether these two conditions are linked and whether PTC with …

Clinical and Pathological Features and the BRAFV600E Mutation in Patients with Papillary Thyroid Carcinoma with and without Concurrent Hashimoto Thyroiditis

SK Kim, KH Song, SD Lim, YC Lim, YB Yoo, JS Kim… - Thyroid, 2009 - liebertpub.com
Background: It has been reported that patients with papillary thyroid carcinoma (PTC) have a
high incidence of background Hashimoto thyroiditis (HT); however, the linkage of HT to PTC …

RAS mutations in indeterminate thyroid nodules are predictive of the follicular variant of papillary thyroid carcinoma

JH An, KH Song, SK Kim, KS Park, YB Yoo… - Clinical …, 2015 - Wiley Online Library
Objective RAS mutations are the most common mutations in thyroid nodules with
indeterminate cytology by fine‐needle aspiration cytology (FNAC), and are mutually …

[HTML][HTML] Association between BRAF and RAS mutations, and RET rearrangements and the clinical features of papillary thyroid cancer

J Ming, Z Liu, W Zeng, Y Maimaiti, Y Guo… - … journal of clinical and …, 2015 - ncbi.nlm.nih.gov
Objective: To evaluate the significance of BRAF V600E and Ras mutations, and RET
rearrangements in papillary thyroid cancer (PTC) in the South central region of China …

Detection of papillary thyroid carcinoma by analysis of BRAF and RET/PTC1 mutations in fine-needle aspiration biopsies of thyroid nodules

TJ Musholt, C Fottner, MM Weber, W Eichhorn… - World journal of …, 2010 - Springer
Background Activating mutations of the oncogene BRAF or rearrangements of the tyrosine
kinase receptor RET are observed in up to 80% of papillary thyroid carcinomas (PTCs). The …