[HTML][HTML] Genome-Wide Association Study in an Admixed Case Series Reveals IL12A as a New Candidate in Behçet Disease

JH Kappen, C Medina-Gomez, PM Hagen, L Stolk… - PloS one, 2015 - journals.plos.org
Introduction The etiology of Behçet's disease (BD) is unknown, but widely considered an
excessive T-cell mediated inflammatory response in a genetically susceptible host. Recent …

Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease

EF Remmers, F Cosan, Y Kirino, MJ Ombrello… - Nature …, 2010 - nature.com
Behçet's disease is a genetically complex disease of unknown etiology characterized by
recurrent inflammatory attacks affecting the orogenital mucosa, eyes and skin. We performed …

The immunogenetics of Behçet's disease: A comprehensive review

M Takeuchi, DL Kastner, EF Remmers - Journal of autoimmunity, 2015 - Elsevier
Behçet's disease is a chronic multisystem inflammatory disorder characterized mainly by
recurrent oral ulcers, ocular involvement, genital ulcers, and skin lesions, presenting with …

Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci

N Mizuki, A Meguro, M Ota, S Ohno, T Shiota… - Nature …, 2010 - nature.com
Behçet's disease is a chronic systemic inflammatory disorder characterized by four major
manifestations: recurrent ocular symptoms, oral and genital ulcers and skin lesions. We …

[HTML][HTML] Microarray and whole-exome sequencing analysis of familial Behçet's disease patients

D Okuzaki, K Yoshizaki, T Tanaka, T Hirano… - Scientific Reports, 2016 - nature.com
Behçet's disease (BD), a chronic systemic inflammatory disorder, is characterized by
recurrent oral and genital mucous ulcers, uveitis and skin lesions. We performed DNA …

Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behcet's disease susceptibility

M Takeuchi, N Mizuki, A Meguro, MJ Ombrello… - Nature …, 2017 - nature.com
Abstract We analyzed 1,900 Turkish Behçet's disease cases and 1,779 controls genotyped
with the Immunochip. The most significantly associated SNP was rs1050502, a tag SNP for …

Identification of susceptibility SNPs in IL10 and IL23R-IL12RB2 for Behçet's disease in Han Chinese

H Yu, M Zheng, L Zhang, H Li, Y Zhu, L Cheng… - Journal of Allergy and …, 2017 - Elsevier
Background Although previous genome-wide association studies in various cohorts have
identified several susceptibility loci underlying Behçet's disease (BD), this has not yet led to …

[HTML][HTML] Identification of possible pathogenic pathways in Behçet's disease using genome-wide association study data from two different populations

B Bakir-Gungor, EF Remmers, A Meguro… - European Journal of …, 2015 - nature.com
Behçet's disease (BD) is a multi-system inflammatory disorder of unknown etiology. Two
recent genome-wide association studies (GWASs) of BD confirmed a strong association with …

Association study of IL10 and IL23R–IL12RB2 in Iranian patients with Behçet's disease

JM Xavier, F Shahram, F Davatchi, A Rosa… - Arthritis & …, 2012 - Wiley Online Library
Objective Independent replication of the findings from genome‐wide association studies
(GWAS) remains the gold standard for results validation. Our aim was to test the association …

IL10 polymorphisms associated with Behcet's disease in Chinese Han

Z Wu, W Zheng, J Xu, F Sun, H Chen, P Li, S Chen… - Human immunology, 2014 - Elsevier
Objective IL-10 is a potent anti-inflammatory cytokine that plays important roles in the
pathogenesis of Behçet's disease (BD). Two genome-wide association studies have …