[HTML][HTML] Genome-Wide Association Study in an Admixed Case Series Reveals IL12A as a New Candidate in Behçet Disease
JH Kappen, C Medina-Gomez, PM Hagen, L Stolk… - PloS one, 2015 - journals.plos.org
Introduction The etiology of Behçet's disease (BD) is unknown, but widely considered an
excessive T-cell mediated inflammatory response in a genetically susceptible host. Recent …
excessive T-cell mediated inflammatory response in a genetically susceptible host. Recent …
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease
Behçet's disease is a genetically complex disease of unknown etiology characterized by
recurrent inflammatory attacks affecting the orogenital mucosa, eyes and skin. We performed …
recurrent inflammatory attacks affecting the orogenital mucosa, eyes and skin. We performed …
The immunogenetics of Behçet's disease: A comprehensive review
M Takeuchi, DL Kastner, EF Remmers - Journal of autoimmunity, 2015 - Elsevier
Behçet's disease is a chronic multisystem inflammatory disorder characterized mainly by
recurrent oral ulcers, ocular involvement, genital ulcers, and skin lesions, presenting with …
recurrent oral ulcers, ocular involvement, genital ulcers, and skin lesions, presenting with …
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci
N Mizuki, A Meguro, M Ota, S Ohno, T Shiota… - Nature …, 2010 - nature.com
Behçet's disease is a chronic systemic inflammatory disorder characterized by four major
manifestations: recurrent ocular symptoms, oral and genital ulcers and skin lesions. We …
manifestations: recurrent ocular symptoms, oral and genital ulcers and skin lesions. We …
[HTML][HTML] Microarray and whole-exome sequencing analysis of familial Behçet's disease patients
D Okuzaki, K Yoshizaki, T Tanaka, T Hirano… - Scientific Reports, 2016 - nature.com
Behçet's disease (BD), a chronic systemic inflammatory disorder, is characterized by
recurrent oral and genital mucous ulcers, uveitis and skin lesions. We performed DNA …
recurrent oral and genital mucous ulcers, uveitis and skin lesions. We performed DNA …
Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behcet's disease susceptibility
M Takeuchi, N Mizuki, A Meguro, MJ Ombrello… - Nature …, 2017 - nature.com
Abstract We analyzed 1,900 Turkish Behçet's disease cases and 1,779 controls genotyped
with the Immunochip. The most significantly associated SNP was rs1050502, a tag SNP for …
with the Immunochip. The most significantly associated SNP was rs1050502, a tag SNP for …
Identification of susceptibility SNPs in IL10 and IL23R-IL12RB2 for Behçet's disease in Han Chinese
H Yu, M Zheng, L Zhang, H Li, Y Zhu, L Cheng… - Journal of Allergy and …, 2017 - Elsevier
Background Although previous genome-wide association studies in various cohorts have
identified several susceptibility loci underlying Behçet's disease (BD), this has not yet led to …
identified several susceptibility loci underlying Behçet's disease (BD), this has not yet led to …
[HTML][HTML] Identification of possible pathogenic pathways in Behçet's disease using genome-wide association study data from two different populations
B Bakir-Gungor, EF Remmers, A Meguro… - European Journal of …, 2015 - nature.com
Behçet's disease (BD) is a multi-system inflammatory disorder of unknown etiology. Two
recent genome-wide association studies (GWASs) of BD confirmed a strong association with …
recent genome-wide association studies (GWASs) of BD confirmed a strong association with …
Association study of IL10 and IL23R–IL12RB2 in Iranian patients with Behçet's disease
Objective Independent replication of the findings from genome‐wide association studies
(GWAS) remains the gold standard for results validation. Our aim was to test the association …
(GWAS) remains the gold standard for results validation. Our aim was to test the association …
IL10 polymorphisms associated with Behcet's disease in Chinese Han
Objective IL-10 is a potent anti-inflammatory cytokine that plays important roles in the
pathogenesis of Behçet's disease (BD). Two genome-wide association studies have …
pathogenesis of Behçet's disease (BD). Two genome-wide association studies have …