Chronic kidney disease (CKD) is characterized by loss of renal function. The pathological
processes involved in the progression of this condition are already known, but the molecular …

Recovery from acute renal failure (ARF) requires the replacement of injured cells with new
cells that restore tubule epithelial integrity. We described recently the expression of a wide …

Recovery from acute renal failure (ARF) requires the replacement of injured cells by new
cells that are able to restore tubule epithelial integrity. We have recently described the …

Aims: The role of angiogenesis in the pathophysiology of chronic renal diseases is not clear,
yet. The expression of proangiogenic growth factors was evaluated in the experimental …

Several studies have shown that hepatocyte growth factor (HGF) ameliorates chronic renal
failure, but its mechanism of action is unclear. This study was designed to test the delivery of …

Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may
mediate autocrine fibroblast proliferation. Background Interstitial fibroblasts play a critical …

Therapeutic effects of acidic fibroblast growth factor on postischemic renal injury were
evaluated in a rat model of bilateral renal ischemia (60 minutes) and reperfusion (7 days) …

Background In diabetic nephropathy, tubulointerstitial fibrosis is an important component of
renal injury. Transforming growth factor (TGF)-β is a key cytokine that is involved in the …

TGF-β1 induces proliferation in human renal fibroblasts via induction of basic fibroblast
growth factor (FGF-2). Background The prognosis of primary renal disease is often …

Matrix accumulation in the renal tubulointerstitium is predictive of a progressive decline in
renal function. Transforming growth factor-β1 (TGF-β1) and, more recently, connective tissue …