Sulbactam, a class A β-lactamase inhibitor, added to cefoperazone either at a fixed 8 mg/L
level of sulbactam or at a level of fixed cefoperazone: sulbactam ratio (2: 1) would constitute …

Objectives: This study aims to assess the in vitro activity of different cefoperazone–
sulbactam ratios against different multidrug-resistant organisms (MDROs). Materials and …

Cefoperazone with 2 and 4 μg/ml of sulbactam and in a 2: 1 ratio was tested against 1258
clinical isolates of Gram-positive and Gram-negative bacteria, as well as against Gram …

Cefoperazone was tested against 554 clinical isolates alone and with sulbactam in three
combinations. The addition of sulbactam in low concentrations (≤ 4 µg/ml) improved the …

Among 28,000 isolates of the family Enterobacteriaceae and nonfermenters isolated at
multiple medical centers, 1,084 (4%) were resistant to cefoperazone (MIC, greater than or …

Due to their wide spectrum of activity, good pharmacokinetics, established clinical efficacy
and high tolerability, cephalosporins are among the most widely used antibiotics worldwide …

Abstract β-Lactamase inhibitors such as sulbactam are (β-lactam compounds that have low
antimicrobial activity but are able to inhibit enzymes (β-lactamases) that destroy j3-lactam …

Three concentrations of the penicillanic acid sulfone, sulbactam were tested in combination
with cefoperazone against 632 recent clinical bacterial isolates. Cefoperazone was effective …

Abstract Background β-Lactam (BL)/β-lactamase inhibitor (BLI) combinations are widely
used for the treatment of Gram-negative infections. Cefepime has not been widely studied in …

Objectives This study aims to assess the in vitro activity of cefoperazone alone and different
cefoperazone-sulbactam ratios against different inoculum sizes of multidrug resistant …