Multi-target design strategies for the improved treatment of Alzheimer's disease

P Zhang, S Xu, Z Zhu, J Xu - European journal of medicinal chemistry, 2019 - Elsevier
Alzheimer's disease (AD) is a multifactorial syndrome resulting in profound misery and
poses a substantial burden on human health, economy, and society throughout the world …

Multi-target-directed ligands in Alzheimer's disease treatment

M Bajda, N Guzior, M Ignasik… - Current medicinal …, 2011 - ingentaconnect.com
Among the various drug discovery methods, a very promising modern approach consists in
designing multi-target-directed ligands (MTDLs). This methodology has been specifically …

Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands

L Blaikie, G Kay, PKT Lin - MedChemComm, 2019 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, and a major
cause of death worldwide. The number of people suffering from this debilitating disorder is …

Developments with multi-target drugs for Alzheimer's disease: An overview of the current discovery approaches

JF González, AR Alcántara, AL Doadrio… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Alzheimer's disease (AD), the most common type of dementia among older
adults, is a chronic neurodegenerative pathology that causes a progressive loss of cognitive …

Perspectives for new and more efficient multifunctional ligands for Alzheimer′ s disease therapy

A Zagórska, A Jaromin - Molecules, 2020 - mdpi.com
Despite tremendous research efforts at every level, globally, there is still a lack of effective
drugs for the treatment of Alzheimer′ s disease (AD). The biochemical mechanisms of this …

Multi-target directed drugs as a modern approach for drug design towards Alzheimer's disease: an update

M de Freitas Silva, KST Dias, VS Gontijo… - Current Medicinal …, 2018 - ingentaconnect.com
Alzheimer's disease (AD) is a progressive multifactorial neurodegenerative disorder.
Currently, no effective treatment is available and this is due to multiple factors involved in …

Multi-target directed drugs: a modern approach for design of new drugs for the treatment of Alzheimer's disease

K Simone Tranches Dias… - Current …, 2014 - ingentaconnect.com
Alzheimer's disease (AD) is a complex neurodegenerative disorder with a multi-faceted
pathogenesis. So far, the therapeutic paradigm “one-compound-one-target” has failed and …

The multifactorial nature of Alzheimer's disease for developing potential therapeutics

M Carmo Carreiras, E Mendes… - Current topics in …, 2013 - ingentaconnect.com
Alzheimerβs disease (AD) is a multifactorial neurodegenerative disorder with several target
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …

Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease

T Wang, X Liu, J Guan, S Ge, MB Wu, J Lin… - European Journal of …, 2019 - Elsevier
Complex diseases (eg, Alzheimer's disease) or infectious diseases are usually caused by
complicated and varied factors, including environmental and genetic factors. Multi-target …

Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease

R Leon, AG Garcia… - Medicinal research …, 2013 - Wiley Online Library
With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …