The mechanisms through which maternal immunization can modulate offspring thymic
maturation of lymphocytes are not fully understood. Here, we aimed to evaluate whether …

The mechanisms through which maternal immunization can modulate offspring thymic
maturation of lymphocytes are not fully understood. Here, we aimed to evaluate whether …

Background: There is strong evidence that reduced exposures to microbial compounds
triggering innate immune responses early in life are critical for the development of allergic …

Results Preconception OVA immunization induced a marked reduction in IL-4 secretion by
TCD4+ cells of WT offspring when compared with offspring from non-immunized mothers …

The regulation of offspring allergy development mediated by maternal immunization was
evidenced by several groups, and this mechanism seems to involve the induction of …

Background Previous studies suggested that maternal farm exposure during pregnancy
modulates early immune development toward an allergy-protective status potentially …

Background The precise mechanism involved in the acquisition of the IL‐17+ profile of γδT
cells, the ligands responsible for this change, and whether this default is acquired during …

TH17 and Treg cells have a reciprocal development pathway. 5 Both cells play an important
role in the induction and perpetuation of inflammatory responses during infection, and also …

BACKGROUND: Maternal atopy is a strong predictor for the development of childhood
allergic diseases. The underlying mechanisms are ill defined, yet regulatory T (Treg) and …

Newborns are characterized by poor responses to vaccines. Defective B cell responses and
a Th2-type polarization can account for this impaired protection in early life. We in this study …