Crosstalk between phosphorylation and O‐Glc NA cylation: friend or foe
A wide variety of protein post‐translational modifications (PTM s) decorate cellular proteins,
regulating their structure, interactions and ultimately their function. The density of co …
regulating their structure, interactions and ultimately their function. The density of co …
Elucidating crosstalk mechanisms between phosphorylation and O-GlcNAcylation
AC Leney, D El Atmioui, W Wu… - Proceedings of the …, 2017 - National Acad Sciences
Proteins can be modified by multiple posttranslational modifications (PTMs), creating a PTM
code that controls the function of proteins in space and time. Unraveling this complex PTM …
code that controls the function of proteins in space and time. Unraveling this complex PTM …
Uncovering post-translational modification-associated protein–protein interactions
In living systems, the chemical space and functional repertoire of proteins are dramatically
expanded through the post-translational modification (PTM) of various amino acid residues …
expanded through the post-translational modification (PTM) of various amino acid residues …
Post-translational modifications induce significant yet not extreme changes to protein structure
F Xin, P Radivojac - Bioinformatics, 2012 - academic.oup.com
Motivation: A number of studies of individual proteins have shown that post-translational
modifications (PTMs) are associated with structural rearrangements of their target proteins …
modifications (PTMs) are associated with structural rearrangements of their target proteins …
[HTML][HTML] Systematic analysis of the in situ crosstalk of tyrosine modifications reveals no additional natural selection on multiply modified residues
Recent studies have indicated that different post-translational modifications (PTMs)
synergistically orchestrate specific biological processes by crosstalks. However, the …
synergistically orchestrate specific biological processes by crosstalks. However, the …
Complex regulatory mechanisms mediated by the interplay of multiple post-translational modifications
V Csizmok, JD Forman-Kay - Current opinion in structural biology, 2018 - Elsevier
Highlights•Multiple PTMs can coordinately determine a functional outcome.•Functional
consequences depend on the effects, number, positioning and type of PTMs.•PTM interplay …
consequences depend on the effects, number, positioning and type of PTMs.•PTM interplay …
[HTML][HTML] Systematic analysis of the impact of phosphorylation and O-GlcNAcylation on protein subcellular localization
The subcellular localization of proteins is critical for their functions in eukaryotic cells and is
tightly correlated with protein modifications. Here, we comprehensively investigate the …
tightly correlated with protein modifications. Here, we comprehensively investigate the …
Characterizing post-translational modifications and their effects on protein conformation using NMR spectroscopy
The diversity of the cellular proteome substantially exceeds the number of genes coded by
the DNA of an organism because one or more residues in a majority of eukaryotic proteins …
the DNA of an organism because one or more residues in a majority of eukaryotic proteins …
[HTML][HTML] Decoding post-translational modification crosstalk with proteomics
Post-translational modification (PTM) of proteins allows cells to regulate protein functions,
transduce signals and respond to perturbations. PTMs expand protein functionality and …
transduce signals and respond to perturbations. PTMs expand protein functionality and …
PTMcode: a database of known and predicted functional associations between post-translational modifications in proteins
Post-translational modifications (PTMs) are involved in the regulation and structural
stabilization of eukaryotic proteins. The combination of individual PTM states is a key to …
stabilization of eukaryotic proteins. The combination of individual PTM states is a key to …