[HTML][HTML] Alzheimer's disease pathophysiology in the retina

BP Gaire, Y Koronyo, DT Fuchs, H Shi… - Progress in Retinal and …, 2024 - Elsevier
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …

Ocular indicators of Alzheimer's: exploring disease in the retina

NJ Hart, Y Koronyo, KL Black… - Acta neuropathologica, 2016 - Springer
Although historically perceived as a disorder confined to the brain, our understanding of
Alzheimer's disease (AD) has expanded to include extra-cerebral manifestation, with …

Alzheimer's retinopathy: seeing disease in the eyes

N Mirzaei, H Shi, M Oviatt, J Doustar… - Frontiers in …, 2020 - frontiersin.org
The neurosensory retina emerges as a prominent site of Alzheimer's disease (AD)
pathology. As a CNS extension of the brain, the neuro retina is easily accessible for …

Retinal changes in Alzheimer's disease—integrated prospects of imaging, functional and molecular advances

VB Gupta, N Chitranshi, J den Haan, M Mirzaei… - Progress in retinal and …, 2021 - Elsevier
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …

Retinal biomarkers of Alzheimer disease

CS Lee, RS Apte - American journal of ophthalmology, 2020 - Elsevier
Purpose To address challenges associated with identifying retinal biomarkers for
Alzheimer's disease (AD) and strategies for future investigation of novel ophthalmologic …

Retinal dysfunction in Alzheimer's disease and implications for biomarkers

C Liao, J Xu, Y Chen, NY Ip - Biomolecules, 2021 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that manifests as
cognitive deficits and memory decline, especially in old age. Several biomarkers have been …

[HTML][HTML] Understanding the brain through aging eyes

M Blazes, CS Lee - Advances in geriatric medicine and research, 2021 - ncbi.nlm.nih.gov
The eye and brain share common mechanisms of aging and disease, thus the retina is an
essential source of accessible information about neurodegenerative processes occurring in …

Visual and ocular manifestations of Alzheimer's disease and their use as biomarkers for diagnosis and progression

FZ Javaid, J Brenton, L Guo, MF Cordeiro - Frontiers in neurology, 2016 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia affecting the growing aging
population today, with prevalence expected to rise over the next 35 years. Clinically, patients …

Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer's disease in the 3xTg-AD mouse model

A Grimaldi, C Brighi, G Peruzzi, D Ragozzino… - Cell Death & …, 2018 - nature.com
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. In the
pathogenesis of AD a pivotal role is played by two neurotoxic proteins that aggregate and …

Alzheimer's disease and retinal neurodegeneration

L Guo, J Duggan, MF Cordeiro - Current Alzheimer Research, 2010 - ingentaconnect.com
Alzheimer's disease (AD) is the major cause of dementia in the world. Although the
entorhinal cortex and hippocampal complex are best known as the sites of early pathology …