Evaluation and refinement of a field‐portable drinking water toxicity sensor utilizing electric cell–substrate impedance sensing and a fluidic biochip

MW Widder, LM Brennan, EA Hanft… - Journal of Applied …, 2015 - Wiley Online Library
The US Army's need for a reliable and field‐portable drinking water toxicity sensor was the
catalyst for the development and evaluation of an electric cell–substrate impedance sensing …

Preparation and testing of impedance-based fluidic biochips with RTgill-W1 cells for rapid evaluation of drinking water samples for toxicity

LM Brennan, MW Widder, MK McAleer… - JoVE (Journal of …, 2016 - jove.com
This manuscript describes how to prepare fluidic biochips with Rainbow trout gill epithelial
(RTgill-W1) cells for use in a field portable water toxicity sensor. A monolayer of RTgill-W1 …

A portable cell-based impedance sensor for toxicity testing of drinking water

TM Curtis, MW Widder, LM Brennan, SJ Schwager… - Lab on a Chip, 2009 - pubs.rsc.org
A major limitation to using mammalian cell-based biosensors for field testing of drinking
water samples is the difficulty of maintaining cell viability and sterility without an on-site cell …

Long-term storage and impedance-based water toxicity testing capabilities of fluidic biochips seeded with RTgill-W1 cells

LM Brennan, MW Widder, LEJ Lee… - Toxicology in vitro, 2012 - Elsevier
Rainbow trout gill epithelial cells (RTgill-W1) are used in a cell-based biosensor that can
respond within one hour to toxic chemicals that have the potential to contaminate drinking …

Improved cell sensitivity and longevity in a rapid impedance‐based toxicity sensor

TM Curtis, J Tabb, L Romeo… - Journal of Applied …, 2009 - Wiley Online Library
A number of toxicity sensors for testing field water using a range of eukaryotic cell types
have been proposed, but it has been difficult to identify sensors with both appropriate …

Selection of a battery of rapid toxicity sensors for drinking water evaluation

WH van der Schalie, RR James, TP Gargan II - Biosensors and …, 2006 - Elsevier
Comprehensive identification of chemical contaminants in Army field water supplies can be
a lengthy process, but rapid analytical methods suitable for field use are limited. A …

A lab-on-chip cell-based biosensor for label-free sensing of water toxicants

F Liu, AN Nordin, F Li, I Voiculescu - Lab on a Chip, 2014 - pubs.rsc.org
This paper presents a lab-on-chip biosensor containing an enclosed fluidic cell culturing
well seeded with live cells for rapid screening of toxicants in drinking water. The sensor is …

Suitability of invertebrate and vertebrate cells in a portable impedance-based toxicity sensor: temperature mediated impacts on long-term survival

TM Curtis, AM Collins, BD Gerlach, LM Brennan… - Toxicology in vitro, 2013 - Elsevier
Using ECIS (electric cell-substrate impedance sensing) to monitor the impedance of
vertebrate cell monolayers provides a sensitive measure of toxicity for a wide range of …

A mediator-free whole-cell electrochemical biosensing system for sensitive assessment of heavy metal toxicity in water

Y Yang, Z Fang, YY Yu, YZ Wang… - Water Science and …, 2019 - iwaponline.com
A bioelectrochemical sensing system (BES) based on electroactive bacteria (EAB) has been
used as a new and promising tool for water toxicity assessment. However, most EAB can …

[HTML][HTML] Toxicity studies using mammalian cells and impedance spectroscopy method

X Zhang, F Li, AN Nordin, J Tarbell… - Sensing and bio-sensing …, 2015 - Elsevier
This research presents a study of cell-based Electric Cell-substrate Impedance Sensing
(ECIS) sensors employed for testing toxicants in real-time. Mammalian cells are exposed to …