The association of hepatic steatosis with hepatic insulin resistance and type 2 diabetes has
prompted investigators to elucidate the underlying mechanism. In this review we focus on …

Hepatic lipid accumulation has been implicated in the development of insulin resistance, but
translational evidence in humans is limited. We investigated the relationship between liver …

Increased hepatic lipid content is associated with hepatic as well as whole‐body insulin
resistance and is typical for individuals with type 2 diabetes mellitus. However, whether …

Numerous studies conducted on obese humans and various rodent models of obesity have
identified a correlation between hepatic lipid content and the development of insulin …

Although ample evidence links hepatic lipid accumulation with hepatic insulin resistance,
the mechanistic basis of this association is incompletely understood and controversial …

Lipid abnormalities such as obesity, increased circulating free fatty acid levels, and excess
intramyocel-lular lipid accumulation are frequently associated with insulin resistance. These …

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Hepatic insulin resistance is a principal component of type 2 diabetes, but the cellular and
molecular mechanisms responsible for its pathogenesis remain unknown. Recent studies …

Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and
accounts for many of its symptoms and complications, efforts to understand the …

A central paradox in type 2 diabetes is the apparent selective nature of hepatic insulin
resistance—wherein insulin fails to suppress hepatic glucose production yet continues to …