A tumorigenic anchorage-dependent cell line (H-91) was established in culture from an azo-
dye-induced rat ascites hepatoma. When grown in a glucose-containing medium the cells …

Rat liver cytoplasm (postnuclear supernatant) has a low aerobic glycolytic rate in the
presence of added glucose, ATP, ADP, Pi, and NAD+, whereas cytoplasm from Ehrlich …

A detailed investigation concerned with localizing hexokinase in the Novikoff ascites tumor
is presented. At least 50% of the total hexokinase activity was shown by differential and …

Recent studies from this laboratory have demonstrated that a form of bexokinase
characteristic of rapidly growing, highly glycolytic tumor cells is bound to an outer …

Previous studies from this laboratory have shown that mitochondrial bound hexokinase is
markedly elevated in highly glycolytic hepatoma cells (Parry, DM, and Pedersen, PL (1983) …

The particulate hexokinase of ascites tumor, Sarcoma 37, is shown to be mitochondrial. The
activity is readily solubilized by glucose 6-phosphate, ribonucleoside triphosphates, or high …

The incorporation of 2-deoxy-d-[14 C] glucose by cultured Novikoff rat hepatoma cells was
investigated as a function of the deoxyglucose concentration in the medium. The …

One of the most characteristic phenotypes of rapidly growing cancer cells is their propensity
to catabolize glucose at high rates. Type II hexokinase, which is expressed at high levels in …

To elucidate the reasons for glycolytic deviation commonly found in brain tumors,
hexokinase (HK) activity, mitochondria-HK binding, oxidative phosphorylation and …

In rapidly growing tumor cells exhibiting high glucose catabolic rates, the enzyme
hexokinase is markedly elevated and bound in large amounts (50-80% of the total cell …