Aging, polypharmacy (concurrent use of≥ 5 medications), and functional impairment are
global healthcare challenges. However, knowledge of the age/sex-specific effects of …

Males and females may respond differently to medications, yet knowledge about sexual
dimorphisms in the effects of polypharmacy remains limited, particularly in aging. This study …

Polypharmacy (use of≥ 5 medications) and increasing Drug Burden Index (DBI) score
(measure of person's total exposure to anticholinergic/sedative medications) are associated …

The potential harmful effects of polypharmacy (concurrent use of 5 or more drugs) are
difficult to investigate in an experimental design in humans. Moreover, there is a lack of …

Introduction Polypharmacy, defined as the use of 5 or more medications is associated with
multiple adverse outcomes in older adults, including falls and slow gait velocity. However …

A major challenge in the health care system is the lack of knowledge about the possible
harmful effects of multiple drug treatments in old age. The present study aims to characterize …

Objective To map out the studies that have investigated the associations of polypharmacy
and/or potentially inappropriate medication (PIM) use with physical activity and sedentary …

We aimed to develop a mouse model of polypharmacy, primarily to establish whether short-
term exposure to polypharmacy causes adverse geriatric outcomes. We also investigated …

Objectives With their broad spectrum of action, psychotropic drugs are among the most
common medications prescribed to the elderly. Consequently, the number of older adults …

Introduction Studies have shown that use of medicines with sedative or anticholinergic
properties is associated with a decline in physical function; however, the effects have not …