Molecular imaging of bone marrow mononuclear cell survival and homing in murine peripheral artery disease

KEA van der Bogt, AA Hellingman, MA Lijkwan… - JACC: Cardiovascular …, 2012 - jacc.org
Objectives: This study aims to provide insight into cellular kinetics using molecular imaging
after different transplantation methods of bone marrow–derived mononuclear cells (MNCs) …

Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease

C Heeschen, R Lehmann, J Honold, B Assmus… - Circulation, 2004 - Am Heart Assoc
Background—Cell therapy with bone marrow–derived stem/progenitor cells is a novel option
for improving neovascularization and cardiac function in ischemic heart disease. Circulating …

Intra-arterial transplantation of adult bone marrow cells restores blood flow and regenerates skeletal muscle in ischemic limbs

Q Liu, Z Chen, T Terry, JM McNatt… - Vascular and …, 2009 - journals.sagepub.com
Objective: Bone marrow cell therapy promotes angiogenesis, but the cellular fate of bone
marrow cells (BMCs) in the absence of immunosuppressant interventions is unclear. We …

In vivo MR imaging of bone marrow cells trafficking to atherosclerotic plaques

B Qiu, F Gao, P Walczak, J Zhang, S Kar… - Journal of Magnetic …, 2007 - Wiley Online Library
Purpose To develop a magnetic resonance imaging (MRI)‐based method to monitor in vivo
trafficking of bone marrow (BM) cells to atherosclerotic lesions. Materials and Methods BM …

[HTML][HTML] Transplantation of bone marrow derived monocytes: a novel approach for augmentation of arteriogenesis in a murine model of femoral artery ligation

A Francke, S Weinert, RH Strasser… - American journal of …, 2013 - ncbi.nlm.nih.gov
Therapeutic augmentation of collateral artery growth (arteriogenesis) is of tremendous
clinical interest. Since monocytes home to areas of arteriogenesis and create a local …

Therapeutic neovascularization by transplantation of mobilized peripheral blood mononuclear cells for limb ischemia

S Li, B Zhou, ZC Han - Thrombosis and haemostasis, 2006 - thieme-connect.com
Autolougous transplantation of granulocyte colony-stimulating factor (G-CSF)-mobilized
human peripheral blood mononuclear cells (PBMNCs) improves limb ischemia in patients …

Molecular MRI of hematopoietic stem-progenitor cells: in vivo monitoring of gene therapy and atherosclerosis

B Qiu, X Yang - Nature Clinical Practice Cardiovascular Medicine, 2008 - nature.com
A characteristic feature of atherosclerotic cardiovascular disease is the diffuse involvement
of arteries across the entire human body and the presence of multiple, simultaneous lesions …

Histological changes after implantation of autologous bone marrow mononuclear cells for chronic critical limb ischemia

B Pignon, MA Sevestre, D Chatelain… - Bone marrow …, 2007 - nature.com
Animal experiment models have demonstrated that implantation of autologous bone marrow
mononuclear cells (BM-MNC) is an effective technique for inducing therapeutic …

Therapeutic targeting of the stem cell niche in experimental hindlimb ischemia

C Napoli, S William-Ignarro, R Byrns… - Nature Clinical Practice …, 2008 - nature.com
Background The custom microenvironment'vascular niche'is a potential therapeutic target for
several pathophysiological conditions. Osteoblasts regulate the hematopoietic stem cell …

Molecular imaging of bone marrow mononuclear cell homing and engraftment in ischemic myocardium

AY Sheikh, SA Lin, F Cao, Y Cao, KEA van der Bogt… - Stem …, 2007 - academic.oup.com
Bone marrow mononuclear cell (BMMC) therapy shows promise as a treatment for ischemic
heart disease. However, the ability to monitor long-term cell fate remains limited. We …