The mechanisms involved in the genesis of chronic obstructive pulmonary disease (COPD)
are poorly defined. This area is complicated and difficult to model because COPD consists of …

Objectives To review the animal models of COPD, and to compare these data to those found
in humans. Results Smoke-induced animal models can produce emphysema, although the …

Chronic exposure of laboratory animals to cigarette smoke reproduces many of the
anatomic/physiologic lesions (emphysema, small-airway remodeling and pulmonary …

Introduction: Chronic obstructive pulmonary disease (COPD) is a leading global cause of
mortality and chronic morbidity. Inhalation of cigarette smoke is the principal risk factor for …

Chronic obstructive pulmonary disease (COPD) is a major global health problem and is
predicted to become the third most common cause of death by 2020. Apart from the …

Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation, that is
not fully reversible, and that is associated with an abnormal inflammatory response of the …

COPD (chronic obstructive pulmonary disease) is a major incurable global health burden
and will become the third largest cause of death in the world by 2020. It is currently believed …

ABSTRACT COPD is a major cause of global mortality and morbidity but current treatments
are poorly effective. This is because the underlying mechanisms that drive the development …

The pathogenesis of chronic obstructive pulmonary disease (COPD) is based on the innate
and adaptive inflammatory immune response to the inhalation of toxic particles and gases …

Mouse models of chronic obstructive pulmonary disease (COPD) focus on airway
inflammation and lung histology, but their use has been hampered by the lack of pulmonary …