Ribonucleotide Reductase (RNR) is a rate-limiting enzyme in the production of
deoxyribonucleoside triphosphates (dNTPs), which are essential substrates for DNA repair …

Hydroxyurea, an inhibitor of ribonucleotide reductase (RR) and DNA synthesis, has been
studied as a radiation sensitizer in clinical trials for approximately 3 decades. Most of the …

PURPOSE Ribonucleotide reductase is the rate-limiting enzyme in the de novo synthesis of
deoxyribonucleotide triphosphates, which are utilized in both DNA synthesis and DNA …

Ribonucleotide reductase (RR), the rate limiting enzyme in the synthesis and repair of DNA,
has been studied as a target for inhibition in the treatment of cancer for many years. While …

Ribonucleotide reductase (RR), the rate-limiting enzyme in the de novo synthesis of
deoxynucleotide triphosphates (dNTPs), is a potential target for cancer therapy. We …

Abstract Kunos, CA, Chiu, S., Pink, J. and Kinsella, TJ Modulating Radiation Resistance by
Inhibiting Ribonucleotide Reductase in Cancers with Virally or Mutationally Silenced p53 …

Cells exposed to hypoxia experience replication stress but do not accumulate DNA damage,
suggesting sustained DNA replication. Ribonucleotide reductase (RNR) is the only enzyme …

Accurate DNA replication and repair is essential for proper development, growth and tumor-
free survival in all multicellular organisms. A key requirement for the maintenance of …

Background Pancreatic cancer has an extremely poor prognosis and is one of the most
chemoresistant cancers. Targeting cancer cell transcriptional complexes may enhance …

Background: Cisplatin is widely used as a cancer therapeutic for many types of cancers. It
mediates the formation of DNA adducts which impair DNA replication and transcription, and …