Structure and function in the human brain are closely related. At the onset of psychosis,
brain imaging studies have identified robust changes in brain function and structure, but no …

Typical antipsychotic drugs act on the dopaminergic system, blocking the dopamine type 2
(D2) receptors. Atypical antipsychotics have lower affinity and occupancy for the …

Importance Recent data suggest that treatment with antipsychotics is associated with
reductions in cortical gray matter in patients with schizophrenia. These findings have led to …

Background: Despite impressive advancements in early interventions in psychosis, there is
an urgent need of robust neurobiological markers to improve the predictive value of …

Abstract Changes in brain volume are a common finding in Magnetic Resonance Imaging
(MRI) studies of people with psychosis and numerous longitudinal studies suggest that …

BackgroundThe potential effects of antipsychotic drugs on brain structure represent a key
factor in understanding neuroanatomical changes in psychosis. This review addresses two …

Objective: This review critically examines the structural neuroimaging evidence in psychotic
illness, with a focus on longitudinal imaging across the first-episode psychosis and ultra …

Importance Prescriptions for antipsychotic medications continue to increase across many
brain disorders, including off-label use in children and elderly individuals. Concerning …

Background Individuals at clinical high risk (CHR) who progress to fully psychotic symptoms
have been observed to show a steeper rate of cortical gray matter reduction compared with …

Importance Brain imaging studies have identified robust changes in brain structure and
function during the development of psychosis, but the contribution of abnormal brain …