The propensity of the hepatic macrophages (Kupffer cells) to rapidly intercept particulate
materials from the blood has been frustrating in redirecting intravenously injected …

Hepatic macrophage populations include different types of cells with plastic properties that
can differentiate into diverse phenotypes to modulate their properties in response to different …

The rapid recognition of intravenously injected colloidal carriers, such as liposomes and
polymeric nanospheres from the blood by Kupffer cells, has initiated a surge of development …

Effective delivery of therapeutic and diagnostic nanoparticles is dependent on their ability to
accumulate in diseased tissues. However, most nanoparticles end up in liver macrophages …

Numerous types of nanoparticles are being designed for systemic and targeted drug
delivery. However, keeping nanoparticles in blood for sufficiently long times so as to allow …

Nanoparticles represent highly promising platforms for the development of imaging and
therapeutic agents, including those that can either be detected via more than one imaging …

Cellular hitchhiking leverages the use of circulatory cells to enhance the biological outcome
of nanoparticle drug delivery systems, which often suffer from poor circulation time and …

Nanoparticles are nanomaterials with three external nanoscale dimensions and an average
size ranging from 1 to 1000 nm. Nanoparticles have gained notoriety in technological …

The development of nanoparticle platforms with long in vivo circulation half-life has long
been one of the major goals in the field of cancer drug delivery. Long-circulating …

In this Perspective, we describe current challenges and recent advances in efficient delivery
and targeting of nanoparticles in vivo. We discuss cancer therapy, nanoparticle–biomolecule …