Genetic analysis of right heart structure and function in 40,000 people
Congenital heart diseases often involve maldevelopment of the evolutionarily recent right
heart chamber. To gain insight into right heart structure and function, we fine-tuned deep …
heart chamber. To gain insight into right heart structure and function, we fine-tuned deep …
Genome-wide association analysis reveals insights into the genetic architecture of right ventricular structure and function
Right ventricular (RV) structure and function influence the morbidity and mortality from
coronary artery disease (CAD), dilated cardiomyopathy (DCM), pulmonary hypertension and …
coronary artery disease (CAD), dilated cardiomyopathy (DCM), pulmonary hypertension and …
Integrated multi-omic characterization of congenital heart disease
MC Hill, ZA Kadow, H Long, Y Morikawa, TJ Martin… - Nature, 2022 - nature.com
The heart, the first organ to develop in the embryo, undergoes complex morphogenesis that
when defective results in congenital heart disease (CHD). With current therapies, more than …
when defective results in congenital heart disease (CHD). With current therapies, more than …
Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages
Heart development is a continuous process involving significant remodeling during
embryogenesis and neonatal stages. To date, several groups have used single-cell …
embryogenesis and neonatal stages. To date, several groups have used single-cell …
Genome-wide analysis of left ventricular image-derived phenotypes identifies fourteen loci associated with cardiac morphogenesis and heart failure development
Background: The genetic basis of left ventricular (LV) image-derived phenotypes, which play
a vital role in the diagnosis, management, and risk stratification of cardiovascular diseases …
a vital role in the diagnosis, management, and risk stratification of cardiovascular diseases …
Genome-wide array analysis of normal and malformed human hearts
Background—We present the first genome-wide cDNA array analysis of human congenitally
malformed hearts and attempted to partially elucidate these complex phenotypes. Most …
malformed hearts and attempted to partially elucidate these complex phenotypes. Most …
High heritability of ascending aortic diameter and trans-ancestry prediction of thoracic aortic disease
Enlargement of the aorta is an important risk factor for aortic aneurysm and dissection, a
leading cause of morbidity in the developed world. Here we performed automated extraction …
leading cause of morbidity in the developed world. Here we performed automated extraction …
Utility of machine learning algorithms in assessing patients with a systemic right ventricle
Aims To investigate the utility of novel deep learning (DL) algorithms in recognizing
transposition of the great arteries (TGA) after atrial switch procedure or congenitally …
transposition of the great arteries (TGA) after atrial switch procedure or congenitally …
Deep learning for detecting congenital heart disease in the fetus
SA Morris, KN Lopez - Nature Medicine, 2021 - nature.com
Deep learning for detecting congenital heart disease in the fetus | Nature Medicine Skip to main
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Spatially distinct genetic determinants of aortic dimensions influence risks of aneurysm and stenosis
Background The left ventricular outflow tract (LVOT) and ascending aorta are spatially
complex, with distinct pathologies and embryologic origins. Prior work examined the …
complex, with distinct pathologies and embryologic origins. Prior work examined the …