Identifying TME signatures for cervical cancer prognosis based on GEO and TCGA databases

WT Xia, WR Qiu, WK Yu, ZC Xu, SH Zhang - Heliyon, 2023 - cell.com
The mortality rate from cervical cancer (CESC), a malignant tumor that affects women, has
increased significantly globally in recent years. The discovery of biomarkers points to a …

Tumor microenvironment characterization in cervical cancer identifies prognostic relevant gene signatures

L Peng, G Hayatullah, H Zhou, S Chang, L Liu, H Qiu… - PloS One, 2021 - journals.plos.org
Objective The aim of this study is to systematically analyze the transcriptional sequencing
data of cervical cancer (CC) to find an Tumor microenvironment (TME) prognostic marker to …

Identification of tumor microenvironment and DNA methylation-related prognostic signature for predicting clinical outcomes and therapeutic responses in cervical …

B Liu, J Zhai, W Wang, T Liu, C Liu, X Zhu… - Frontiers in Molecular …, 2022 - frontiersin.org
Background: Tumor microenvironment (TME) has been reported to have a strong
association with tumor progression and therapeutic outcome, and epigenetic modifications …

A 5-gene DNA methylation signature is a promising prognostic biomarker for early-stage cervical cancer

H Chen, H Li, L Wang, Y Li, CY Yang - Journal of Obstetrics and …, 2022 - Taylor & Francis
The demographic information and overall survival (OS) of patients with cervical cancer
(CC)(pathological stage: IA–IIA) were extracted from the TCGA database. A univariate and …

Identification of key genes associated with cervical cancer by comprehensive analysis of transcriptome microarray and methylation microarray

MY Liu, H Zhang, YJ Hu, YW Chen… - Oncology …, 2016 - spandidos-publications.com
Cervical cancer is the second most commonly diagnosed type of cancer and the third
leading cause of cancer‑associated mortality in women. The current study aimed to …

Integrative analysis of DNA methylation and gene expression identified cervical cancer-specific diagnostic biomarkers

W Xu, M Xu, L Wang, W Zhou, R Xiang, Y Shi… - Signal transduction and …, 2019 - nature.com
Cervical cancer is the leading cause of death among women with cancer worldwide. Here,
we performed an integrative analysis of Illumina HumanMethylation450K and RNA-seq data …

Identification of prognosis-related genes in the cervical cancer immune microenvironment

L Yang, Y Yang, M Meng, W Wang, S He, Y Zhao… - Gene, 2021 - Elsevier
Background Cervical cancer is the fourth most commonly diagnosed cancer in women
worldwide. The metastasis and invasion of this type of cancer are closely related to the …

Mining of prognosis-related genes in cervical squamous cell carcinoma immune microenvironment

J Ma, P Cheng, X Chen, C Zhou, W Zheng - PeerJ, 2020 - peerj.com
Purpose The aim of this study was to explore the effective immune scoring method and mine
the novel and potential immune microenvironment-related diagnostic and prognostic …

Tumor DNA methylation profiles enable diagnosis, prognosis prediction, and screening for cervical cancer

J Tu, S Chen, S Wu, T Wu, R Fan… - International journal of …, 2022 - Taylor & Francis
Background DNA-methylation-based machine learning algorithms have demonstrated
powerful diagnostic capabilities, and these tools are currently emerging in many fields of …

Integrative bioinformatics approaches to screen potential prognostic immune-related genes and drugs in the cervical cancer microenvironment

Z Zhao, J Li, H Li, NY Yuan Wu, P Ou-Yang, S Liu… - Frontiers in …, 2020 - frontiersin.org
In developing countries, cervical cancer is still the major cause of cancer-related death
among women. To better understand the correlation between tumor microenvironment …