The majority of critically ill intensive care unit (ICU) patients with severe sepsis develop ICU-
acquired weakness (ICUAW) characterized by loss of muscle mass, reduction in myofiber …

Survival from critical illness is often the beginning of an arduous journey of recovery from
physical disability related to critical illness polyneuropathy (CIP) and myopathy (CIM) that …

Skeletal muscle is one of the most abundant and highly plastic tissues. The ubiquitin–
proteasome system (UPS) is recognised as a major intracellular protein degradation system …

Background The ubiquitin-proteasome pathway (UPP) is a major protein degradation
pathway that is activated during sepsis and has been proposed as a therapeutic target for …

Summary Background Data Patients with sepsis and other catabolic conditions, such as
severe trauma, cancer, and fasting, suffer significant loss of body protein, the majority of …

Recent studies suggest that sepsis stimulates ubiquitin-dependent protein breakdown in
skeletal muscle. The 20S proteasome is the catalytic core of the ubiquitin-dependent …

Improvements in health in the past decades have resulted in increased numbers of the
elderly in both developed and developing regions of the world. Advances in therapy have …

Muscle atrophy complicates many diseases as well as aging, and its presence predicts both
decreased quality of life and survival. Much work has been conducted to define the …

Intensive care unit-acquired weakness (ICUAW) occurs in critically ill patients stemming from
the critical illness itself, and results in sustained disability long after the ICU stay. Weakness …

Muscle wasting during sepsis reflects increased expression and activity of the ubiquitin–
proteasome proteolytic pathway and is at least in part mediated by glucocorticoids. The …