Rifaximin-extended intestinal release induces remission in patients with moderately active Crohn's disease

C Prantera, H Lochs, M Grimaldi, S Danese… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Bacteria might be involved in the development and persistence of
inflammation in patients with Crohn's disease (CD), and antibiotics could be used in therapy …

Adjunctive antibiotic therapy with rifaximin may help reduce Crohn's disease activity

I Shafran, P Burgunder - Digestive diseases and sciences, 2010 - Springer
Aims Enteric bacteria are thought to contribute to the pathogenesis of Crohn's disease, and
antibiotics may be an effective therapy. This study examines the efficacy of the nonsystemic …

Is rifaximin effective in maintaining remission in Crohn's disease?

AO Jigaranu, O Nedelciuc, A Blaj, M Badea… - Digestive …, 2014 - karger.com
Background: Recent studies indicate that persistent intestinal inflammation in patients with
Crohn's disease (CD) might be caused by abnormal intestinal microbiota. This hypothesis …

An open-label evaluation of rifaximin in the treatment of active Crohn's disease

I Shafran, LK Johnson - Current medical research and opinion, 2005 - Taylor & Francis
Objective: This open-label study was conducted as a preliminary assessment of rifaximin
(200 mg TID for 16 weeks) for the treatment of active Crohn's disease in patients (n= 29) with …

Antibiotic treatment of Crohn's disease: results of a multicentre, double blind, randomized, placebo‐controlled trial with rifaximin

C Prantera, H Lochs, M Campieri… - Alimentary …, 2006 - Wiley Online Library
Background Clinicians often employ antibiotics in Crohn's disease. Rifaximin is active
against bacteria frequently found in the intestinal mucosa of Crohn's disease patients. Aim …

[HTML][HTML] Rifaximin in the treatment of inflammatory bowel disease

M Guslandi - World journal of gastroenterology: WJG, 2011 - ncbi.nlm.nih.gov
The gut microbiota plays a role in promoting and maintaining inflammation in inflammatory
bowel diseases (IBD), hence the rationale for the use of antibiotics in the treatment of those …

Rifaximin modulates the colonic microbiota of patients with Crohn's disease: an in vitro approach using a continuous culture colonic model system

S Maccaferri, B Vitali, A Klinder, S Kolida… - Journal of …, 2010 - academic.oup.com
Objectives Rifaximin, a rifamycin derivative, has been reported to induce clinical remission
of active Crohn's disease (CD), a chronic inflammatory bowel disorder. In order to …

the potential mechanisms of action of rifaximin in the management of inflammatory bowel diseases

RB Sartor - Alimentary pharmacology & therapeutics, 2016 - Wiley Online Library
Background Gut microbiota dysbiosis contributes to the pathogenesis of inflammatory bowel
diseases (IBD). Although the microbiota's role in IBD pathogenesis, specifically Crohn's …

Effects of rifaximin treatment and retreatment in nonconstipated IBS subjects

M Pimentel, W Morales, K Chua, G Barlow… - Digestive diseases and …, 2011 - Springer
Recent evidence suggests a role for gut bacteria and antibiotics in the pathophysiology and
treatment of irritable bowel syndrome (IBS), respectively. While the benefits of the antibiotic …

A controlled trial comparing ciprofloxacin with mesalazine for the treatment of active Crohn's disease

JF Colombel, M Lémann, M Cassagnou… - Official journal of the …, 1999 - journals.lww.com
OBJECTIVE: The aim of this randomized controlled study was to investigate the efficacy of
ciprofloxacin compared with mesalazine in treating active Crohn's disease. METHODS …