[HTML][HTML] Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity

S Quesada-Vazquez, A Castells-Nobau, J Latorre… - Cell Reports …, 2023 - cell.com
The gut microbiota contributes to the pathophysiology of non-alcoholic fatty liver disease
(NAFLD). Histidine is a key energy source for the microbiota, scavenging it from the host. Its …

[HTML][HTML] Activation of the gut microbiota-kynurenine-liver axis contributes to the development of nonalcoholic hepatic steatosis in nondiabetic adults

G Sui, L Jia, D Quan, N Zhao, G Yang - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
The contribution of gut-liver signaling to the development of non-alcoholic hepatic steatosis
(NHS) in non-diabetic adults remains unclear. We therefore performed comprehensive 16S …

[HTML][HTML] Microbial intervention as a novel target in treatment of non-alcoholic fatty liver disease progression

Y Zhou, T Zheng, H Chen, Y Li, H Huang… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Emerging evidence suggests a close link between gut microbiota and
non-alcoholic fatty liver disease (NAFLD). In this study, we aimed to investigate the …

[HTML][HTML] Advances in the Involvement of Gut Microbiota in Pathophysiology of NAFLD

X Jiang, J Zheng, S Zhang, B Wang, C Wu… - Frontiers in …, 2020 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis and
progresses to non-steatohepatitis (NASH) when the liver displays overt inflammatory …

[HTML][HTML] Alleviation of hepatic steatosis: Dithizone-related gut microbiome restoration during paneth cell dysfunction

S Zhang, HM Tun, D Zhang, HT Chau… - Frontiers in …, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD), the world's most common chronic liver disease, is
increasingly linked to gut dysbiosis. Paneth cells secrete antimicrobial peptides that regulate …

Gut microbiota and obesity: implications for fecal microbiota transplantation therapy

Y Kang, Y Cai - Hormones, 2017 - Springer
Obesity is a major public health issue as it is causally associated with several chronic
disorders, including type-2 diabetes, cerebrovascular disease (CVD), and cancer. In the …

[HTML][HTML] An integrated understanding of the rapid metabolic benefits of a carbohydrate-restricted diet on hepatic steatosis in humans

A Mardinoglu, H Wu, E Bjornson, C Zhang… - Cell metabolism, 2018 - cell.com
A carbohydrate-restricted diet is a widely recommended intervention for non-alcoholic fatty
liver disease (NAFLD), but a systematic perspective on the multiple benefits of this diet is …

Identification of gut microbial lysine and histidine degradation and CYP-dependent metabolites as biomarkers of fatty liver disease

A Driuchina, J Hintikka, M Lehtonen… - MBio, 2023 - Am Soc Microbiol
Numerous studies have described specific metabolites as biomarkers of severe liver
diseases, but very few have measured gut microbiota (GM)-produced metabolites in fatty …

[HTML][HTML] Gut microbiota–mitochondrial inter-talk in non-alcoholic fatty liver disease

Q Zhang, W Xing, Q Wang, Z Tang, Y Wang… - Frontiers in …, 2022 - frontiersin.org
The increasing prevalence of non-alcoholic fatty liver disease (NAFLD), which is a
progressive disease, has exerted huge a healthcare burden worldwide. New investigations …

Amlodipine, an anti‐hypertensive drug, alleviates non‐alcoholic fatty liver disease by modulating gut microbiota

Y Li, D Zhao, M Qian, J Liu, C Pan… - British journal of …, 2022 - Wiley Online Library
Background and Purpose Non‐alcoholic fatty liver disease (NAFLD) represents a severe
public health problem. It often coexists with hypertension in the context of metabolic …