Multiple mechanisms of tolerance are induced by oral antigen. Low doses favor active
suppression, whereas higher doses favor clonal anergy/deletion. Oral antigen induces T …

Oral tolerance is classically defined as the suppression of immune responses to antigens
(Ag) that have been administered previously by the oral route. Multiple mechanisms of …

Oral tolerance is a long recognized method to induce peripheral immune tolerance. Oral
tolerance has been used successfully to treat animal models of autoimmune diseases and is …

The gut‐associated lymphoid tissue is the largest immune organ in the body and is the
primary route by which we are exposed to antigens. Tolerance induction is the default …

Oral tolerance is defined as the specific suppression of humoral and/or cellular immune
responses to an antigen by administration of the same antigen through the oral route. Due to …

Oral tolerance was first detailed almost 100 years ago, and since then, it has been shown
repeatedly that feeding a wide variety of nonpathogenic antigens can inhibit subsequent …

Publisher Summary This chapter discusses the mechanisms and therapeutic applications of
oral tolerance. The most striking characteristic of the gut mucosa is the abundance of the …

Oral tolerance is the immunologic mechanism by which the mucosal immune system
maintains unresponsiveness to the myriad of antigens in the mucosal environment which …

Oral tolerance, the specific suppression of cellular and/or humoral immune responses to an
antigen by prior administration of the antigen by the oral route, probably evolved to prevent …

Center for Neurologic Diseases and Laboratory of Transplantation, Brigham and Women's
Hospital and Division of Rheumatology, Beth Israel Hospital and Harvard Medical School …