[HTML][HTML] Synergistic Mechanisms of Selected Polyphenols in Overcoming Chemoresistance and Enhancing Chemosensitivity in Colorectal Cancer

KW Hon, R Naidu - Antioxidants, 2024 - mdpi.com
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. Despite significant
advances in medical treatment, chemotherapy as monotherapy can lead to substantial side …

Natural polyphenols as targeted modulators in colon cancer: molecular mechanisms and applications

J Long, P Guan, X Hu, L Yang, L He, Q Lin… - Frontiers in …, 2021 - frontiersin.org
Colon cancer commonly develops from long-term chronic inflammation in the intestine and
seriously threatens human health. Natural polyphenols have been valued as a crucial …

Natural polyphenols for treatment of colorectal cancer

Y Zhang, K Liu, C Yan, Y Yin, S He, L Qiu, G Li - Molecules, 2022 - mdpi.com
Colorectal cancer (CRC) is a prevalent and serious gastrointestinal malignancy with high
mortality and morbidity. Chemoprevention refers to a newly emerged strategy that uses …

Polyphenols in colorectal cancer: current state of knowledge including clinical trials and molecular mechanism of action

MN Alam, M Almoyad, F Huq - BioMed research international, 2018 - Wiley Online Library
Polyphenols have been reported to have wide spectrum of biological activities including
major impact on initiation, promotion, and progression of cancer by modulating different …

Greasing the Wheels of Pharmacotherapy for Colorectal Cancer: The Role of Natural Polyphenols

C Niu, J Zhang, P Okolo - Current Nutrition Reports, 2023 - Springer
Abstract Purpose of Review The main purpose of this review, mainly based on preclinical
studies, is to summarize the pharmacological and biochemical evidence regarding natural …

Polyphenolic coumpounds in Chemoprevention of colon cancer-Targets and signaling pathways

E Rudolf, H Andelova… - Anti-Cancer Agents in …, 2007 - ingentaconnect.com
Colorectal cancer is one of the leading causes of premature death in people worldwide. Due
to the fact that malignant conversion of normal colonic cells requires several steps and often …

Polyphenols: immunomodulatory and therapeutic implication in colorectal cancer

AM Mileo, P Nisticò, S Miccadei - Frontiers in immunology, 2019 - frontiersin.org
Polyphenolic compounds, widely present in fruits, vegetables, and cereals, have potential
benefits for human health and are protective agents against the development of …

Phenolic phytochemicals for prevention and treatment of colorectal cancer: A critical evaluation of in vivo studies

S De, S Paul, A Manna, C Majumder, K Pal, N Casarcia… - Cancers, 2023 - mdpi.com
Simple Summary Colorectal cancer (CRC) is a significant cause of death worldwide. The
inefficacy of the current treatment regimens is reflected in the frequent recurrence and …

Dietary polyphenols: promising adjuvants for colorectal cancer therapies

L Bracci, A Fabbri, M Del Corno, L Conti - Cancers, 2021 - mdpi.com
Simple Summary Colorectal cancer is a leading cause of death worldwide. Despite the
development of novel surgical and therapeutic strategies, 50% of patients relapse after …

Cytotoxic and chemopreventive activity of polyphenols and their derivatives in colon cancer

H Jha, R Arora - Colon Cancer Diagnosis and Therapy Vol. 3, 2022 - Springer
Polyphenols include widely distributed groups of plant metabolites that are the integral part
of human diet. Cereals, fruits and vegetables with polyphenolic compounds have potential …