BACKGROUND: Previous studies have not extensively examined the association of
hyperuricemia and adverse outcomes in systolic heart failure (HF) in relation to xanthine …

OBJECTIVE: Uric acid (UA) levels are frequently increased in patients with heart failure (HF),
and may be an indicator of a poor prognosis and an innovative target for treatment. We …

Objective: To examine whether allopurinol is associated with any alteration in mortality and
hospitalisations in patients with chronic heart failure (CHF). This hypothesis is based on …

STUDY OBJECTIVE: The aim of this study was to explore the prognostic role of serum uric
acid (UA) measurement in the hospital and long-term mortality assessment in subjects with …

Background—Oxidative stress may contribute to heart failure (HF) progression. Inhibiting
xanthine oxidase in hyperuricemic HF patients may improve outcomes. Methods and …

ABSTRACT Background and Aim: Increased xanthine oxidase (XO) activity may contribute
to heart failure pathophysiology. This study evaluated whether a XO inhibitor, allopurinol …

Background Hyperuricemia is associated with reduced survival among patients with heart
failure (HF), but the effect of gout on HF outcomes is unknown. A recent randomized trial …

Hyperuricemia increases the risk of heart failure, and higher levels of serum uric acid are
seen in patients who have worse ventricular function, functional capacity, and prognosis …

Serum uric acid (SUA) is a product of xanthine oxidase (XO). Apoptosis and tissue hypoxia
lead to increased purine catabolism, which, in turn, increases XO activity and subsequently …

Background The prognostic impact of hyperuricemia on long-term clinical outcomes in
patients with chronic heart failure (HF) has been investigated in observational registries and …