What can be expected in normal aging, and where does normal aging stop and pathological
neurodegeneration begin? With the slow progression of age-related dementias such as …

Alzheimer's disease (AD) is associated with functional and structural alterations in a
distributed network of brain regions supporting memory and other cognitive domains …

Normal aging is often difficult to distinguish from the earliest stages of Alzheimer's disease.
Years before clinical memory deficits manifest, amyloid-β deposits in the cortex in many …

This study examined the functionality of the medial temporal lobe (MTL) and posterior
cingulate (PC) in mild cognitive impairment amnestic type (MCI), a syndrome that puts …

The number of individuals older than 65 years is projected to exceed 71.5 million in the year
2030, which is twice the number alive during the year 2000. While this dramatic increase in …

The results of studies from the Washington University Alzheimer Disease (AD) Research
Center and those from other centers and investigators regarding the neuropathologic …

Human studies are reviewed concerning whether “aging”-related mechanisms contribute to
Alzheimer's disease (AD) pathogenesis. AD is defined by specific neuropathology: neuritic …

For 70 years after Alois Alzheimer described a disorder of tangle-and-plaque dementia,
Alzheimer's disease was a condition of the relatively young. Definitions of Alzheimer's …

Controversy persists regarding whether Alzheimer's disease (AD) is a distinct entity or
instead exists on a continuum with nondemented aging. To explore this issue, volumetric …

Although both normal aging and Alzheimer's disease (AD) are associated with regional
cortical atrophy, few studies have directly compared the spatial patterns and magnitude of …