Oxidative/nitrosative stress is proposed to be a critical factor in various diseases, including
liver pathologies. Antioxidants derived from medicinal plants have been studied extensively …

Internal metabolism and environmental toxicant exposure can be caused to generate
reactive oxygen species in human organelles which lead to oxidative stress. The nuclear …

Oxidative stress and inflammation play an important role in the pathophysiological changes
of liver diseases. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor …

Abstract Nuclear erythroid 2-related factor 2 (Nrf2) is a central regulator of antioxidative
response elements-mediated gene expression. It has a significant role in adaptive …

Background Nuclear factor erythroid 2-related factor (Nrf2), a stress-activated transcription
factor, has been documented to induce a defense mechanism against oxidative stress …

Background Liver fibrosis, in which hepatocyte damage and inflammatory response play
critical roles, is a physiological response to chronic or iterative liver injury and can progress …

Activated hepatic stellate cells (HSCs) and myofibroblasts are the main producers of
extracellular matrix (ECM) proteins that form the fibrotic tissue that leads to hepatic fibrosis …

In response to stress signal, nuclear factor‐erythroid 2‐related factor 2 (Nrf2) induces the
expression of target genes involved in antioxidant defense and detoxification. Nrf2 activity is …

To investigate the role of Nrf2 as a master defense against the hepatotoxicity produced by
various chemicals, Nrf2‐null, wild‐type, Keap1‐knock down (Keap1‐Kd) and Keap1 …

Oxidative stress and inflammation are the most important pathogenic events in the
development and progression of liver diseases. Nuclear erythroid 2-related factor 2 (Nrf2) is …