Evidence suggests that uncontrolled immune system responses and their components play
a significant role in developing rheumatoid arthritis (RA), which is considered an …

Rheumatoid arthritis (RA) is a chronic autoimmune disease of unexplained causes. Its
pathological features include synovial tissue hyperplasia, inflammatory cell infiltration in joint …

Rheumatoid arthritis (RA) is a multisystemic and inflammatory autoimmune disease
characterized by joint destruction. The C–C motif chemokine receptor 2 (CCR2) is mainly …

CCR2 has been widely considered as a potential therapeutic target for autoimmune
disease, particularly rheumatoid arthritis, and various CCR2 blocking agents have been …

CCR2, and its principle ligand MCP-1/CCL2, have been well documented for their ability to
induce monocyte infiltration and promote the pathogenesis of rheumatoid arthritis and …

Objectives While various monocyte chemokine systems are increased in expression in
osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors in mediating …

Introduction Monocytes/macrophages accumulate in the rheumatoid (RA) synovium where
they play a central role in inflammation and joint destruction. Identification of molecules …

The therapeutic targeting of pro‐inflammatory TNF with neutralising biological anti‐TNF
agents, often in combination with other disease‐modifying anti‐rheumatic drugs, such as the …

The prevailing paradigm is that in human rheumatoid arthritis (RA), the accumulation of
monocytes and T cells in the joint, mediated in part by such CC chemokine receptors …

Objective CCR5 and its ligands (CCL3, CCL4, and CCL5) may play a role in inflammatory
cell recruitment into the joint. However, it was recently reported that CCR5 on T cells and …