Background Although therapeutic hypothermia reduces death or disability after neonatal
encephalopathy in high-income countries, its safety and efficacy in low-income and middle …

Although selective or whole body cooling combined with optimal intensive care improves
outcomes following neonatal encephalopathy in high-income countries, the safety and …

In 2005, the Lancet Neonatal Survival Series1 highlighted the fact that 4 million babies die in
the neonatal period; 99% of these deaths arise in low-income and middle-income countries …

Background Therapeutic hypothermia (TH) is regarded as the most efficacious therapy for
neonatal hypoxic encephalopathy. However, limitations in previous systematic reviews and …

Objectives To examine if therapeutic hypothermia reduces the composite outcome of death,
moderate or severe disability at 18 months or more after mild neonatal encephalopathy …

Background We previously reported early results of a randomized trial of whole-body
hypothermia for neonatal hypoxic–ischemic encephalopathy showing a significant reduction …

Background Hypoxic perinatal brain injury is caused by lack of oxygen to baby's brain and
can lead to death or permanent brain damage. However, the effectiveness of therapeutic …

Although major cooling trials (and subsequent guidelines) excluded babies with mild
encephalopathy, anecdotal evidence suggests that cooling is often offered to these infants …

Background Moderate hypothermia in neonates with hypoxic–ischaemic encephalopathy
might improve survival and neurological outcomes at up to 18 months of age, although …

Background Newborn animal studies and pilot studies in humans suggest that mild
hypothermia following peripartum hypoxia‐ischaemia in newborn infants may reduce …