The year 2015 marks the 50th anniversary since the discovery of the anticancer potential of
cisplatin and it remains just as useful now as it did back then, especially for the treatment of …

Prostate cancer (PCa) is well-recognized as a lipid-enriched tumor. Lipids represent a
diverse array of molecules essential to the cellular structure, defense, energy, and …

Prostate cancer is an androgen-dependent cancer with unique metabolic features compared
to many other solid tumors, and typically does not exhibit the “Warburg effect”. During …

Prostate cancer (PCa) is the most common cancer in men, and more than 10% of men will
be diagnosed with PCa during their lifetime. Patients that are not cured with surgery or …

De novo lipogenesis is a well-described androgen receptor (AR)–regulated metabolic
pathway that supports prostate cancer tumor growth by providing fuel, membrane material …

Despite our most vigorous efforts, prostate cancer remains the second leading cause of
cancer death in men. Understanding the intricacies of androgen metabolism is vital to …

BACKGROUND Emerging evidence suggests that androgens and the androgen receptor
(AR) are important mediators of castration‐resistant prostate cancer (CRPC) progression …

The year 2015 marks the 50th anniversary since the discovery of the anticancer potential of
cisplatin and it remains just as useful now as it did back then, especially for the treatment of …

The link between prostate cancer (PC) development and lipid metabolism is well
established, with AR intimately involved in a number of lipogenic processes involving …

Background: Androgens play an essential role in the development and differentiation of the
prostate gland; their contribution to pathological conditions, such as benign prostatic …