Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment

RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Molecular targets for treating cognitive dysfunction in schizophrenia

JA Gray, BL Roth - Schizophrenia bulletin, 2007 - academic.oup.com
Cognitive impairment is a core feature of schizophrenia as deficits are present in the majority
of patients, frequently precede the onset of other positive symptoms, persist even with …

Systemic hypotheses for generalized cognitive deficits in schizophrenia: a new take on an old problem

D Dickinson, PD Harvey - Schizophrenia bulletin, 2009 - academic.oup.com
The schizophrenia research community, including government, industry, and academia, has
made development of procognitive treatment strategies a priority. Much current research is …

Cognitive deficits and functional outcome in schizophrenia

CR Bowie, PD Harvey - Neuropsychiatric disease and treatment, 2006 - Taylor & Francis
Cognitive dysfunction is a core feature of schizophrenia. Deficits are moderate to severe
across several domains, including attention, working memory, verbal learning and memory …

Translating the basic and clinical cognitive neuroscience of schizophrenia to drug development and clinical trials of antipsychotic medications

MF Green, DL Braff - Biological psychiatry, 2001 - Elsevier
Neurocognitive deficits have become increasingly important defining features of
schizophrenia and its treatment. Multiple domains of neurocognitive functions are impaired …

Cognitive impairment in schizophrenia is the core of the disorder

B Elvevag, TE Goldberg - Critical Reviews™ in Neurobiology, 2000 - dl.begellhouse.com
Patients with schizophrenia exhibit an exceedingly wide range of symptoms from a variety of
domains. The cardinal features are abnormal ideas (such as delusions); abnormal …

Cognitive control deficits in schizophrenia: mechanisms and meaning

TA Lesh, TA Niendam, MJ Minzenberg… - …, 2011 - nature.com
Although schizophrenia is an illness that has been historically characterized by the
presence of positive symptomatology, decades of research highlight the importance of …

Cognitive impairment and functional outcome in schizophrenia and bipolar disorder

MF Green - Journal of Clinical Psychiatry, 2006 - psychiatrist.com
A considerable amount of evidence supports the relationship between cognitive impairment
and functional outcomes in schizophrenia. Cognitive impairment is considered a core …

Schizophrenia and cognitive function

G Kuperberg, S Heckers - Current opinion in neurobiology, 2000 - Elsevier
Schizophrenia is often associated with cognitive deficits, particularly within the domains of
memory and language. Specific cognitive deficits have recently been linked to psychotic …

Executive function, neural circuitry, and genetic mechanisms in schizophrenia

DP Eisenberg, KF Berman - Neuropsychopharmacology, 2010 - nature.com
After decades of research aimed at elucidating the pathophysiology and etiology of
schizophrenia, it has become increasingly apparent that it is an illness knowing few …