[HTML][HTML] Lysophosphatidic acid is associated with neuropathic pain intensity in humans: An exploratory study
K Kuwajima, M Sumitani, M Kurano, K Kano… - PloS one, 2018 - journals.plos.org
The underlying mechanisms of neuropathic pain remain to be elucidated. Basic animal
research has suggested that lysophosphatidic acids, which are bioactive lipids produced by …
research has suggested that lysophosphatidic acids, which are bioactive lipids produced by …
Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid
Lysophosphatidic acid receptor (LPA1) signaling initiates neuropathic pain and several
pathological events in a partial sciatic nerve injury model. Recently, we reported that …
pathological events in a partial sciatic nerve injury model. Recently, we reported that …
Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain
L Ma, H Uchida, J Nagai, M Inoue, J Chun… - Molecular …, 2009 - journals.sagepub.com
Background We previously reported that intrathecal injection of lysophosphatidylcholine
(LPC) induced neuropathic pain through activation of the lysophosphatidic acid (LPA)-1 …
(LPC) induced neuropathic pain through activation of the lysophosphatidic acid (LPA)-1 …
Lysophosphatidic acid receptors (LPARs): potential targets for the treatment of neuropathic pain
Neuropathic pain can arise from lesions to peripheral or central nerve fibres leading to
spontaneous action potential generation and a lowering of the nociceptive threshold …
spontaneous action potential generation and a lowering of the nociceptive threshold …
Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain
L Ma, H Uchida, J Nagai, M Inoue, J Aoki… - Journal of Pharmacology …, 2010 - ASPET
We previously reported that lysophosphatidic acid (LPA) initiates nerve injury-induced
neuropathic pain and its underlying mechanisms. In addition, we recently demonstrated that …
neuropathic pain and its underlying mechanisms. In addition, we recently demonstrated that …
Lysophosphatidic acid: chemical signature of neuropathic pain
H Ueda, H Matsunaga, OI Olaposi, J Nagai - Biochimica et Biophysica Acta …, 2013 - Elsevier
Acute inflammatory pain signal originates from transient hypersensitivity in afferent fibers
when depolarized via injured tissues or proinflammatory cells-derived pronociceptive ligand …
when depolarized via injured tissues or proinflammatory cells-derived pronociceptive ligand …
Identification of the sensory nerve fiber responsible for lysophosphatidic acid-induced allodynia in mice
M Ohsawa, Y Miyabe, H Katsu, S Yamamoto, H Ono - Neuroscience, 2013 - Elsevier
Lysophosphatidic acid (LPA) has been considered one of the molecular culprits for
neuropathic pain. Understanding how LPA changes the function of primary afferent fibers …
neuropathic pain. Understanding how LPA changes the function of primary afferent fibers …
Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki‐16425, a lysophosphatidic acid 1 …
L Ma, M Matsumoto, W Xie, M Inoue… - Journal of …, 2009 - Wiley Online Library
Lysophosphatidic acid is a bioactive lipid mediator with neuronal activities. We previously
reported a crucial role for lysophosphatidic acid 1 receptor‐mediated signaling in …
reported a crucial role for lysophosphatidic acid 1 receptor‐mediated signaling in …
Lysophosphatidic acid signaling is the definitive mechanism underlying neuropathic pain
H Ueda - Pain, 2017 - journals.lww.com
Chemical mediators stimulate their receptors on nociceptor endings of sensory neurons,
activate various types of ion channels through intracellular signaling, and generate action …
activate various types of ion channels through intracellular signaling, and generate action …
Lysophosphatidic acid as the initiator of neuropathic pain
H Ueda - Biological and Pharmaceutical Bulletin, 2011 - jstage.jst.go.jp
The injury-induced intense stimulation of spinal cord neurons causes lysophosphatidic acid
(LPA) biosynthesis. LPA1 receptor activation causes demyelination and sprouting of dorsal …
(LPA) biosynthesis. LPA1 receptor activation causes demyelination and sprouting of dorsal …
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