The underlying mechanisms of neuropathic pain remain to be elucidated. Basic animal
research has suggested that lysophosphatidic acids, which are bioactive lipids produced by …

Lysophosphatidic acid receptor (LPA1) signaling initiates neuropathic pain and several
pathological events in a partial sciatic nerve injury model. Recently, we reported that …

Background We previously reported that intrathecal injection of lysophosphatidylcholine
(LPC) induced neuropathic pain through activation of the lysophosphatidic acid (LPA)-1 …

Neuropathic pain can arise from lesions to peripheral or central nerve fibres leading to
spontaneous action potential generation and a lowering of the nociceptive threshold …

We previously reported that lysophosphatidic acid (LPA) initiates nerve injury-induced
neuropathic pain and its underlying mechanisms. In addition, we recently demonstrated that …

Acute inflammatory pain signal originates from transient hypersensitivity in afferent fibers
when depolarized via injured tissues or proinflammatory cells-derived pronociceptive ligand …

Lysophosphatidic acid (LPA) has been considered one of the molecular culprits for
neuropathic pain. Understanding how LPA changes the function of primary afferent fibers …

Lysophosphatidic acid is a bioactive lipid mediator with neuronal activities. We previously
reported a crucial role for lysophosphatidic acid 1 receptor‐mediated signaling in …

Chemical mediators stimulate their receptors on nociceptor endings of sensory neurons,
activate various types of ion channels through intracellular signaling, and generate action …

The injury-induced intense stimulation of spinal cord neurons causes lysophosphatidic acid
(LPA) biosynthesis. LPA1 receptor activation causes demyelination and sprouting of dorsal …