The use of biomaterials in modern medicine has enabled advanced drug delivery strategies
and led to reduced morbidity and mortality in a variety of interventions such as …

Exposure of nonself surfaces such as those of biomaterials or transplanted cells and organs
to host blood frequently triggers innate immune responses, thereby affecting both their …

The complement system is an important inflammatory mediator during procedures such as
cardiopulmonary bypass and hemodialysis when blood is exposed to large areas of …

Activation of the thrombotic and complement systems is the main recognition and effector
mechanisms in the multiple adverse biological responses triggered when biomaterials or …

The main function of the complement system is pattern recognition of danger. Typical
exogenous danger signals are pathogen associated molecular patterns inducing a …

The development of agonists capable of activating the human complement system by
binding to the C1 complex presents a novel approach for targeted cell killing. Bispecific …

The complement system is an important regulator of both adaptive and innate immunity,
implicating complement as a potential target for immunotherapeutics. We have recently …

The nature of the protein corona forming on biomaterial surfaces can affect the performance
of implanted devices. This study investigated the role of surface chemistry and wettability on …

The complement system is an integral component of the humoral immune system, and
describes a cascade of interacting proteins responsible for the opsonization and lysis of …

Foreign particles and damaged host cells can activate the complement system leading to
their destruction by the host defense system. Factor H (fH) plays a vital role in restricting …