Complement-regulatory biomaterial coatings: Activity and selectivity profile of the factor H-binding peptide 5C6
C Bechtler, S Koutsogiannaki, E Umnyakova, A Hamid… - Acta Biomaterialia, 2023 - Elsevier
The use of biomaterials in modern medicine has enabled advanced drug delivery strategies
and led to reduced morbidity and mortality in a variety of interventions such as …
and led to reduced morbidity and mortality in a variety of interventions such as …
Protection of nonself surfaces from complement attack by factor H-binding peptides: implications for therapeutic medicine
YQ Wu, H Qu, G Sfyroera, A Tzekou, BK Kay… - The Journal of …, 2011 - journals.aai.org
Exposure of nonself surfaces such as those of biomaterials or transplanted cells and organs
to host blood frequently triggers innate immune responses, thereby affecting both their …
to host blood frequently triggers innate immune responses, thereby affecting both their …
Binding of a model regulator of complement activation (RCA) to a biomaterial surface: surface-bound factor H inhibits complement activation
The complement system is an important inflammatory mediator during procedures such as
cardiopulmonary bypass and hemodialysis when blood is exposed to large areas of …
cardiopulmonary bypass and hemodialysis when blood is exposed to large areas of …
Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating
Activation of the thrombotic and complement systems is the main recognition and effector
mechanisms in the multiple adverse biological responses triggered when biomaterials or …
mechanisms in the multiple adverse biological responses triggered when biomaterials or …
Advances in assay of complement function and activation
M Harboe, EB Thorgersen, TE Mollnes - Advanced drug delivery reviews, 2011 - Elsevier
The main function of the complement system is pattern recognition of danger. Typical
exogenous danger signals are pathogen associated molecular patterns inducing a …
exogenous danger signals are pathogen associated molecular patterns inducing a …
Engineering Agonistic Bispecifics to Investigate the Influence of Distance on Surface-Mediated Complement Activation
The development of agonists capable of activating the human complement system by
binding to the C1 complex presents a novel approach for targeted cell killing. Bispecific …
binding to the C1 complex presents a novel approach for targeted cell killing. Bispecific …
Engineering complement activation on polypropylene sulfide vaccine nanoparticles
The complement system is an important regulator of both adaptive and innate immunity,
implicating complement as a potential target for immunotherapeutics. We have recently …
implicating complement as a potential target for immunotherapeutics. We have recently …
Biomaterial surface hydrophobicity-mediated serum protein adsorption and immune responses
RM Visalakshan, MN MacGregor… - … applied materials & …, 2019 - ACS Publications
The nature of the protein corona forming on biomaterial surfaces can affect the performance
of implanted devices. This study investigated the role of surface chemistry and wettability on …
of implanted devices. This study investigated the role of surface chemistry and wettability on …
Fc microparticles can modulate the physical extent and magnitude of complement activity
The complement system is an integral component of the humoral immune system, and
describes a cascade of interacting proteins responsible for the opsonization and lysis of …
describes a cascade of interacting proteins responsible for the opsonization and lysis of …
Multiple ligand binding sites on domain seven of human complement factor H
E Giannakis, DA Male, RJ Ormsby, C Mold… - International …, 2001 - Elsevier
Foreign particles and damaged host cells can activate the complement system leading to
their destruction by the host defense system. Factor H (fH) plays a vital role in restricting …
their destruction by the host defense system. Factor H (fH) plays a vital role in restricting …