[HTML][HTML] AMPK and NRF2: Interactive players in the same team for cellular homeostasis?
E Petsouki, SNS Cabrera, EH Heiss - Free Radical Biology and Medicine, 2022 - Elsevier
NRF2 (Nuclear factor E2 p45‐related factor 2) is a stress responsive transcription factor
lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults …
lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults …
[HTML][HTML] Activated AMPK boosts the Nrf2/HO-1 signaling axis—a role for the unfolded protein response
K Zimmermann, J Baldinger, B Mayerhofer… - Free Radical Biology …, 2015 - Elsevier
In light of the emerging interplay between redox and metabolic signaling pathways we
investigated the potential cross talk between nuclear factor E2-related factor 2 (Nrf2) and …
investigated the potential cross talk between nuclear factor E2-related factor 2 (Nrf2) and …
[HTML][HTML] AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes
M Matzinger, K Fischhuber, D Pölöske, K Mechtler… - Redox biology, 2020 - Elsevier
The transcription factor Nrf2 (nuclear factor (erythroid-derived 2)-like 2) and the kinase
AMPK (AMP-activated protein kinase) participate in the cellular adaptive response to redox …
AMPK (AMP-activated protein kinase) participate in the cellular adaptive response to redox …
Mechanistic studies of the Nrf2-Keap1 signaling pathway
DD Zhang - Drug metabolism reviews, 2006 - Taylor & Francis
Since eukaryotic cells constantly encounter various environmental insults, they have
evolved defense mechanisms to cope with toxicant-and carcinogen-induced oxidative stress …
evolved defense mechanisms to cope with toxicant-and carcinogen-induced oxidative stress …
Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response
The bZIP transcription factor Nrf2 has emerged as a pivotal regulator of intracellular redox
homeostasis by controlling the expression of many endogenous antioxidants and phase II …
homeostasis by controlling the expression of many endogenous antioxidants and phase II …
Nrf2-ARE stress response mechanism: a control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases
Nrf2, a redox sensitive transcription factor, plays a pivotal role in redox homeostasis during
oxidative stress. Nrf2 is sequestered in cytosol by an inhibitory protein Keap1 which causes …
oxidative stress. Nrf2 is sequestered in cytosol by an inhibitory protein Keap1 which causes …
Nrf2/Keap1/ARE signaling: Towards specific regulation
The Nrf2 transcription factor governs the expression of hundreds genes involved in cell
defense against oxidative stress, the hallmark of numerous diseases such as …
defense against oxidative stress, the hallmark of numerous diseases such as …
AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan
A Salminen, JMT Hyttinen, K Kaarniranta - Journal of molecular medicine, 2011 - Springer
Adenosine monophosphate-activated protein kinase (AMPK) is a crucial regulator of energy
metabolic homeostasis and thus a major survival factor in a variety of metabolic stresses and …
metabolic homeostasis and thus a major survival factor in a variety of metabolic stresses and …
Modulation of NRF2: biological dualism in cancer, targets and possible therapeutic applications
M Gallorini, S Carradori, E Panieri, M Sova… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: The nuclear factor erythroid 2-related factor 2 (NRF2)-Kelch-like ECH-
associated protein 1 (KEAP1) system is a master regulator of redox homeostasis and cell …
associated protein 1 (KEAP1) system is a master regulator of redox homeostasis and cell …
Bioactive compounds in oxidative stress-mediated diseases: targeting the NRF2/ARE signaling pathway and epigenetic regulation
M Thiruvengadam, B Venkidasamy, U Subramanian… - Antioxidants, 2021 - mdpi.com
Oxidative stress is a pathological condition occurring due to an imbalance between the
oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 …
oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 …