The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …

Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of
metallophosphohydrolases that specifically cleave the 3′, 5′-cyclic phosphate moiety of …

Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate the cellular levels
of the second messengers, cAMP and cGMP, by controlling their rates of degradation. There …

GAF domains regulate the catalytic activity of certain vertebrate cyclic nucleotide
phosphodiesterases (PDEs) by allosteric, noncatalytic binding of cyclic nucleotides. GAF …

Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and
cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides …

Although cyclic nucleotide phosphodiesterases (PDEs) were described soon after the
discovery of cAMP, their complexity and functions in signaling is only recently beginning to …

The establishment of a Gordon Research Conference devoted to cyclic nucleotide
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …

Cyclic nucleotide phosphodiesterases (PDEs) are a superfamily of enzymes controlling
cellular concentrations of the second messengers cAMP and cGMP. Crystal structures of the …

Recent progress in the field of cyclic nucleotidos has shown that a large array of closely
related proteins is involved in each step of the signal transduction cascade. Nine families of …

Cyclic nucleotide phosphodiesterases (PDEs) that specifically inactivate the intracellular
messengers cAMP and cGMP in a compartmentalized manner represent an important …