B lymphocytes have critical roles as positive and negative regulators of immunity. Their
inhibitory function has been associated primarily with interleukin 10 (IL-10) because B-cell …

B cells regulate immune responses by producing antigen-specific antibodies. However,
specific B-cell subsets can also negatively regulate T-cell immune responses, and have …

Abstract Interleukin-10 (IL-10)-producing regulatory B (Breg) cells suppress autoimmune
disease, and increased numbers of Breg cells prevent host defense to infection and promote …

Abstract Interleukin 17 (IL-17) is a cytokine associated with inflammation, autoimmunity and
defense against some bacteria. Here we show that IL-17 can promote autoimmune disease …

Regulatory T (Treg) cells are a critical sub-population of CD4+ T cells that are essential for
maintaining self tolerance and preventing autoimmunity,, for limiting chronic inflammatory …

To assess the importance of B cell control of T cell differentiation, we analyzed the course of
the T helper type 1 (TH1)-driven disease experimental autoimmune encephalomyelitis in …

Abstract Interleukin-12 (IL-12) is a heterodimeric molecule composed of p35 and p40
subunits. Analyses in vitro have defined IL-12 as an important factor for the differentiation of …

IL-21 regulates the activity and number of IL-10-producing regulatory B cells (B10 cells) that
modulate immune responses and limit diverse autoimmune diseases. A new study …

THE discovery of new cytokines normally relies on a prior knowledge of at least one of their
biological effects, which is used as a criterion either for the purification of the protein or for …

Abstract Interleukin-7 receptor (IL-7R) is genetically associated with susceptibility to multiple
sclerosis. Here we describe that IL-7 is essential for survival and expansion of pathogenic T …