Umbilical cord-derived mesenchymal stromal cells preserve endogenous insulin production in type 1 diabetes: a phase I/II randomised double-blind placebo …

PO Carlsson, D Espes, S Sisay, LC Davies, CIE Smith… - Diabetologia, 2023 - Springer
Aim/hypothesis This study aimed to investigate the safety and efficacy of treatment with
allogeneic Wharton's jelly-derived mesenchymal stromal cells (MSCs) in recent-onset type 1 …

One repeated transplantation of allogeneic umbilical cord mesenchymal stromal cells in type 1 diabetes: an open parallel controlled clinical study

J Lu, S Shen, Q Ling, B Wang, L Li, W Zhang… - Stem cell research & …, 2021 - Springer
Background The preservation or restoration of β cell function in type 1 diabetes (T1D)
remains as an attractive and challengeable therapeutic target. Mesenchymal stromal cells …

Umbilical cord mesenchymal stromal cell with autologous bone marrow cell transplantation in established type 1 diabetes: a pilot randomized controlled open-label …

J Cai, Z Wu, X Xu, L Liao, J Chen, L Huang… - Diabetes …, 2016 - Am Diabetes Assoc
OBJECTIVE To determine the safety and effects on insulin secretion of umbilical cord (UC)
mesenchymal stromal cells (MSCs) plus autologous bone marrow mononuclear cell (aBM …

Long term effects of the implantation of Wharton's jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset type 1 diabetes mellitus

J Hu, X Yu, Z Wang, F Wang, L Wang, H Gao… - Endocrine …, 2013 - jstage.jst.go.jp
1) Stem Cell Research Center, the Affiliated Hospital of Medical College, Qingdao
University, Qingdao 266003, China 2) Endocrinology Department, the Affiliated Hospital of …

Efficacy and safety of umbilical cord-derived mesenchymal stem cells in Chinese adults with type 2 diabetes: a single-center, double-blinded, randomized, placebo …

L Zang, Y Li, H Hao, J Liu, Y Cheng, B Li, Y Yin… - Stem Cell Research & …, 2022 - Springer
Background To determine the efficacy and safety of umbilical cord-derived mesenchymal
stem cells (UC-MSCs) in Chinese adults with type 2 diabetes mellitus (T2DM). Methods In …

Prevention of chronic diabetic complications in type 1 diabetes by co-transplantation of umbilical cord mesenchymal stromal cells and autologous bone marrow: a pilot …

Z Wu, X Xu, J Cai, J Chen, L Huang, W Wu, A Pugliese… - Cytotherapy, 2022 - Elsevier
Background aims To explore the long-term safety and benefit of umbilical cord
mesenchymal stromal cell (MSCs) plus autologous bone marrow mononuclear cell (aBM …

Co‐microencapsulation of human umbilical cord‐derived mesenchymal stem and pancreatic islet‐derived insulin producing cells in experimental type 1 diabetes

P Montanucci, T Pescara, A Greco… - Diabetes/metabolism …, 2021 - Wiley Online Library
Introduction Post‐partum umbilical cord Wharton Jelly‐derived adult mesenchymal stem
cells (hUCMS) hold anti‐inflammatory and immunosuppressive properties. Human …

Therapeutic efficacy of umbilical cord-derived stem cells for diabetes mellitus: a meta-analysis study

DH Kassem, MM Kamal - Stem Cell Research & Therapy, 2020 - Springer
Background Stem cell therapy provides great hope for patients with diabetes mellitus (DM).
DM is a seriously alarming metabolic disease characterized by hyperglycemia and β cell …

Therapeutic efficacy of umbilical cord-derived mesenchymal stem cells in patients with type 2 diabetes

LX Guan, H Guan, HB Li, CA Ren… - Experimental and …, 2015 - spandidos-publications.com
Abstract Type 2 diabetes (T2D) is characterized by progressive and inexorable β‑cell
dysfunction, leading to insulin deficiency. Novel strategies to preserve the remaining β‑cells …

[HTML][HTML] Effectiveness and safety of human umbilical cord-mesenchymal stem cells for treating type 2 diabetes mellitus

XF Lian, DH Lu, HL Liu, YJ Liu, XQ Han… - World Journal of …, 2022 - ncbi.nlm.nih.gov
BACKGROUND Progressive pancreatic β-cell dysfunction is a fundamental part of the
pathology of type 2 diabetes mellitus (T2DM). Cellular therapies offer novel opportunities for …