RON signaling is a key mediator of tumor progression in many human cancers

N Faham, AL Welm - Cold Spring Harbor symposia on …, 2016 - symposium.cshlp.org
With an increasing body of literature covering RON receptor tyrosine kinase function in
different types of human cancers, it is becoming clear that RON has prominent roles in both …

The ron receptor tyrosine kinase: a key regulator of inflammation and cancer progression

X Wang, PA Hankey - Critical Reviews™ in Immunology, 2013 - dl.begellhouse.com
Numerous studies have documented abnormal expression and activation of the Ron
receptor tyrosine kinase in a variety of human malignancies. Here we review the literature …

Ron receptor tyrosine kinase signaling as a therapeutic target

NM Benight, SE Waltz - Expert opinion on therapeutic targets, 2012 - Taylor & Francis
Introduction: Since its discovery nearly 20 years ago, the Ron receptor tyrosine kinase has
been extensively studied. These studies have elucidated many of the major signaling …

Oncogenesis of RON receptor tyrosine kinase: a molecular target for malignant epithelial cancers1

M WANG, H YAO, Y ZHOU - Acta Pharmacologica Sinica, 2006 - Wiley Online Library
Recepteur d'origine nantais (RON) belongs to a subfamily of receptor tyrosine kinases (RTK)
with unique expression patterns and biological activities. RON is activated by a serum …

[HTML][HTML] Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction

MH Wang, R Zhang, YQ Zhou… - Journal of biomedical …, 2013 - ncbi.nlm.nih.gov
The RON receptor tyrosine kinase, a member of the MET proto-oncogene family, is a
pathogenic factor implicated in tumor malignancy. Specifically, aberrations in RON signaling …

An introduction and overview of RON receptor tyrosine kinase signaling

BG Hunt, LH Fox, JC Davis, A Jones, Z Lu, SE Waltz - Genes, 2023 - mdpi.com
RON is a receptor tyrosine kinase (RTK) of the MET receptor family that is canonically
involved in mediating growth and inflammatory signaling. RON is expressed at low levels in …

Met‐related receptor tyrosine kinase Ron in tumor growth and metastasis

PK Wagh, BE Peace, SE Waltz - Advances in cancer research, 2008 - Elsevier
The Ron receptor is a member of the Met family of cell surface receptor tyrosine kinases and
is primarily expressed on epithelial cells and macrophages. The biological response of Ron …

Oncogenic signaling pathways activated by RON receptor tyrosine kinase

A Danilkovitch-Miagkova - Current cancer drug targets, 2003 - ingentaconnect.com
RON (Receptuer d'Origine Nantaise) is a member of the MET receptor tyrosine kinase
family. RON is expressed in various cell types including macrophages, epithelial and …

Ron-receptor tyrosine kinase in tumorigenesis and metastasis

MA Leonis, MN Thobe, SE Waltz - Future oncology, 2007 - Taylor & Francis
The Ron-receptor tyrosine kinase has been increasingly recognized for its tumorigenic
potential in the last decade. Ron-receptor activation leads to the activation of common …

Multiple variants of the RON receptor tyrosine kinase: biochemical properties, tumorigenic activities, and potential drug targets

Y Lu, HP Yao, MH Wang - Cancer letters, 2007 - Elsevier
Aberrant expression of the RON (Recepteur d'Origine Nantais) receptor tyrosine kinase,
accompanied by generation of multiple splicing or truncated variants, contributes to …