Bioactivity and in silico studies of isoquinoline and related alkaloids as promising antiviral agents: an insight

D Sharma, N Sharma, N Manchanda, SK Prasad… - Biomolecules, 2022 - mdpi.com
Viruses are widely recognized as the primary cause of infectious diseases around the world.
The ongoing global pandemic due to the emergence of SARS-CoV-2 further added fuel to …

Indole alkaloids as potential candidates against COVID-19: an in silico study

M Mohseni, H Bahrami, B Farajmand… - Journal of molecular …, 2022 - Springer
COVID-19 has recently grown to be pandemic all around the world. Therefore, efforts to find
effective drugs for the treatment of COVID-19 are needed to improve humans' life quality and …

[HTML][HTML] Structural modification may be a way to make isoquinoline alkaloids efficient antibacterial drugs

H Wang, Y Zhao, H Xu, P Wang, S Chen - Arabian Journal of Chemistry, 2023 - Elsevier
Isoquinoline alkaloids are a kind of small molecular compounds with isoquinoline structure
which widely exist in natural plants. A large number of studies have confirmed that these …

Indole-based compounds as potential drug candidates for SARS-CoV-2

AS Girgis, SS Panda, BM Kariuki, MS Bekheit… - Molecules, 2023 - mdpi.com
The COVID-19 pandemic has posed a significant threat to society in recent times,
endangering human health, life, and economic well-being. The disease quickly spreads due …

Anti-viral activity of bioactive molecules of silymarin against COVID-19 via in silico studies

C Zhang, Y Sui, S Liu, M Yang - Pharmaceuticals, 2023 - mdpi.com
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection drove the
global coronavirus disease 2019 (COVID-19) pandemic, causing a huge loss of human life …

Quinoline and Quinazoline Alkaloids against COVID‐19: An In Silico Multitarget Approach

EMOA Ismail, SW Shantier, MS Mohammed… - Journal of …, 2021 - Wiley Online Library
The recent outbreak of the highly contagious coronavirus disease 2019 (COVID‐19) caused
by the novel coronavirus SARS‐CoV‐2 has created a global health crisis with …

Isoquinoline alkaloids and their antiviral, antibacterial, and antifungal activities and structure-activity relationship

ZX Qing, P Yang, Q Tang, P Cheng… - Current Organic …, 2017 - ingentaconnect.com
Background & Objective: The emergence of multidrug-resistant virus, bacteria and fungi has
created an urgent need for the development of novel antibiotic drugs from natural products …

In-vitro antiviral activity and in-silico targeted study of quinoline-3-carboxylate derivatives against SARS-Cov-2 isolate

RK Mittal, P Purohit, M Sankaranarayanan… - Molecular Diversity, 2023 - Springer
In recent years, the viral outbreak named COVID-19 showed that infectious diseases have a
huge impact on both global health and the financial and economic sectors. The lack of …

Inhibitory effects of selected isoquinoline alkaloids against main protease (Mpro) of SARS-CoV-2, in silico study

M Sadeghi, M Miroliaei - In Silico Pharmacology, 2022 - Springer
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has become a global threat. Despite the production of various vaccines and …

In Silico Identification and Analysis of Potentially Bioactive Antiviral Phytochemicals against SARS‐CoV‐2: A Molecular Docking and Dynamics Simulation Approach

SK Halder, I Sultana, MN Shuvo, A Shil… - BioMed Research …, 2023 - Wiley Online Library
SARS‐CoV‐2, a deadly coronavirus sparked COVID‐19 pandemic around the globe. With
an increased mutation rate, this infectious agent is highly transmissible inducing an …