Immunodeficient mice engrafted with functional human cells and tissues, that is, humanized
mice, have become increasingly important as small, preclinical animal models for the study …

Immunodeficient mice bearing an IL2rγ null mutated gene can be engrafted with functional
human cells and tissues, including human immune systems, following engraftment with …

Immunodeficient mice engrafted with human cells and tissues have provided an exciting
alternative to in vitro studies with human tissues and nonhuman primates for the study of …

Humanized mouse models that have received human cells or tissue transplants are
extremely useful in basic and applied human disease research. Highly immunodeficient …

Significant advances in our understanding of the in vivo functions of human cells and tissues
and the human immune system have resulted from the development of'humanized'mouse …

Abstract “Humanized” mice are a promising translational model for studying human
hematopoiesis and immunity. Their utility has been enhanced by the development of new …

Humanized mice are superior to rodents for preclinical evaluation of the efficacy and safety
of drug candidates using human cells or tissues. During the past decade, humanized mouse …

The study of human-specific infectious agents has been hindered by the lack of optimal
small animal models. More recently development of novel strains of immunodeficient mice …

With an increasing human population, medical research is pushed to progress into an era of
precision therapy. Humanized mice are at the very heart of this new forefront where it is …

With the increase in knowledge resulting from the sequencing of the human genome, the
genetic basis for the underlying differences in individuals, their diseases, and how they …