The current state of peptide drug discovery: back to the future?
A Henninot, JC Collins, JM Nuss - Journal of medicinal chemistry, 2018 - ACS Publications
Over the past decade, peptide drug discovery has experienced a revival of interest and
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …
[HTML][HTML] Peptide therapeutics: current status and future directions
K Fosgerau, T Hoffmann - Drug discovery today, 2015 - Elsevier
Highlights•We provide a SWOT analysis of peptide therapeutics and discuss commercial
aspects.•We comment on emerging peptide technologies and cell-penetrating peptides.• …
aspects.•We comment on emerging peptide technologies and cell-penetrating peptides.• …
The future of peptide‐based drugs
The suite of currently used drugs can be divided into two categories–traditional 'small
molecule'drugs with typical molecular weights of< 500 Da but with oral bioavailability, and …
molecule'drugs with typical molecular weights of< 500 Da but with oral bioavailability, and …
Synthetic therapeutic peptides: science and market
P Vlieghe, V Lisowski, J Martinez, M Khrestchatisky - Drug discovery today, 2010 - Elsevier
The decreasing number of approved drugs produced by the pharmaceutical industry, which
has been accompanied by increasing expenses for R&D, demands alternative approaches …
has been accompanied by increasing expenses for R&D, demands alternative approaches …
Therapeutic peptides: current applications and future directions
L Wang, N Wang, W Zhang, X Cheng, Z Yan… - … and Targeted Therapy, 2022 - nature.com
Peptide drug development has made great progress in the last decade thanks to new
production, modification, and analytic technologies. Peptides have been produced and …
production, modification, and analytic technologies. Peptides have been produced and …
Peptide therapeutics and the pharmaceutical industry: barriers encountered translating from the laboratory to patients
J Rafferty, H Nagaraj, AP McCloskey… - Current Medicinal …, 2016 - ingentaconnect.com
Peptides are receiving increasing interest as clinical therapeutics. These highly tunable
molecules can be tailored to achieve desirable biocompatibility and biodegradability with …
molecules can be tailored to achieve desirable biocompatibility and biodegradability with …
[HTML][HTML] Therapeutic peptides: Historical perspectives, current development trends, and future directions
JL Lau, MK Dunn - Bioorganic & medicinal chemistry, 2018 - Elsevier
Peptide therapeutics have played a notable role in medical practice since the advent of
insulin therapy in the 1920s. Over 60 peptide drugs are approved in the United States and …
insulin therapy in the 1920s. Over 60 peptide drugs are approved in the United States and …
Peptides as 'drugs': the journey so far
S Sachdeva - International journal of peptide research and …, 2017 - Springer
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Trends in peptide drug discovery
Since the introduction of insulin almost a century ago, more than 80 peptide drugs have
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis …
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis …
Peptide Therapeutics 2.0
BG de la Torre, F Albericio - Molecules, 2020 - mdpi.com
In recent years, the peptide drug discovery field has shown a high level of dynamism, with
hundreds of academic groups working on this topic, the creation of new peptide-focused …
hundreds of academic groups working on this topic, the creation of new peptide-focused …