The transient depletion of monocytes alone prior to exposure of macaques to HTLV-1
enhances both HTLV-1WT (wild type) and HTLV-1p12KO (Orf-1 knockout) infectivity, but …

We investigated the impact of monocytes, NK cells, and CD8+ T-cells in primary HTLV-1
infection by depleting cell subsets and exposing macaques to either HTLV-1 wild type …

Peripheral blood monocytes can be classified into three main subsets: CD14++CD16–
(classical), CD14+CD16++(non-classical), and CD14++CD16+(intermediate) which exert …

HTLV-1 can cause serious diseases such as adult T-cell leukemia (ATL) in humans after
chronic asymptomatic latent infection with substantial proviral load. Proviruses are …

Cell-free human T-lymphotropic virus type 1 (HTLV-1) virions are poorly infectious in vitro for
their primary target cells, CD4+ T cells. Here, we show that HTLV-1 can efficiently infect …

Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy of CD4+ T-cells
associated with HTLV-1 infection. In this study, we used the model of immunodeficient NSG …

HTLV-1 orf-I is linked to immune evasion, viral replication and persistence. Examining the orf-
I sequence of 160 HTLV-1-infected individuals; we found polymorphism of orf-I that alters the …

Risk of HAM/TSP depends on HTLV-1 proviral load 3. HTLV-1 proviral load is correlated
with the HTLV-1-specific CTL activity 4. HTLV-1 infection accelerates the turnover of both …

The deltaretroviruses human T cell lymphotropic virus type 1 (HTLV-1) and human T cell
lymphotropic virus type 2 (HTLV-2) have long been believed to differ from retroviruses in …

We show that the squirrel monkey Saimiri sciureus is susceptible to experimental infection
with either syngeneic or allogeneic HTLV-1-immortalized cells. As in humans, such …