The ocular lens is responsible for focusing of light onto the retina and must maintain
transparency to effectively transmit light. Age related nuclear cataract is the most common …

The eye lens is responsible for focusing and transmitting light to the retina. The lens does
this in the absence of organelles, yet maintains transparency for at least 5 decades before …

The ocular lens is a unique tissue that contains an age gradient of cells and proteins ranging
from newly differentiated cells containing newly synthesized proteins to cells and proteins …

The ocular lens proteome undergoes post-translational and progressive degradation as
fiber cells age. The oldest fiber cells and the proteins therein are present at birth and are …

Introduction The goal of this review is to highlight the triumphs and frontiers in measurement
of the lens proteome as it relates to onset of age-related nuclear cataract. As global life …

Cataract, the opacification of the eye lens, is the leading cause of blindness worldwide—it
accounts for approximately 42% of all cases. The lens fibers have the highest protein …

The lenticular fiber cells are comprised of extremely long-lived proteins while still
maintaining an active biochemical state. Dysregulation of these activities has been …

Purpose: The accumulation of damaging posttranslational modifications (PTMs) in lens
proteins with age has been hypothesized as a primary cause of protein aggregation in age …

The lens is an essential component of the ocular system and has a high metabolic demand.
However, the delivery of energy sources such as glucose and waste removal cannot occur …

Purpose: Massive membrane binding of lens proteins occurs after 40 years of age resulting
in a high-density fraction of lipids and proteins. The purpose of this presentation is to …