The homeostasis of bone microenvironment is the foundation of bone health and comprises
2 concerted events: bone formation by osteoblasts and bone resorption by osteoclasts. In …

The bony skeleton, as a structural foundation for the human body, is essential in providing
mechanical function and movement. The human skeleton is a highly specialized and …

The traditional view of skeletal homeostasis as a primarily endocrine activity has been
expanded in recent years following the identification of direct neural pathways controlling …

The brain, which governs most, if not all, physiological functions in the body, from the
complexities of cognition, learning and memory, to the regulation of basal body temperature …

Osteoporosis is caused by a failure of bone homeostasis, but the precise molecular
mechanisms controlling bone homeostasis are largely unknown. Increasing evidence that …

Thanks to integrative physiology, new relationships between organs and homeostatic
functions have emerged. This approach to physiology based on a whole organism approach …

Convincing evidence has accumulated of regulation of bone by the central nervous system.
The neural connection between brain and bone is mediated centrally by classic …

Our understanding of the control of skeletal metabolism has undergone a dynamic shift in
the last two decades, primarily driven by our understanding of energy metabolism. Evidence …

Bone has always been regarded as a merely structural tissue, a “hard” scaffold protecting all
of its “soft” fellows, while they did the rest of the work. In the last few decades this concept …

Abstract In 1997 Professor J. Gorski suggested endocrinology needed new paradigms
(Endocrine News 1997; 22: 4, 12)." Connecting the dots" between diverse facts and ideas …