Developmental studies have revealed the importance of the transcription factor Hand2 in
cardiac development. Hand2 promotes cardiac progenitor differentiation and epithelial …

Embryonic heart formation requires the production of an appropriate number of
cardiomyocytes; likewise, cardiac regeneration following injury relies upon the recovery of …

The precise origins of myocardial progenitors and their subsequent contribution to the
developing heart has been an area of considerable activity within the field of cardiovascular …

The transcription factor HAND2 plays essential roles during cardiogenesis. Hand2
endocardial deletion (H2CKO) results in tricuspid atresia or double inlet left ventricle with …

Cardiogenesis involves the contributions of multiple progenitor pools, including mesoderm-
derived cardiac progenitors known as the first and second heart fields. Disruption of genetic …

Organogenesis involves integration of myriad cell types with reciprocal interactions, each
progressing through successive stages of lineage specification and differentiation …

Rationale: The basic helix–loop–helix (bHLH) transcription factors Hand1 and Hand2 are
essential for embryonic development. Given their requirement for cardiogenesis, it is …

The basic helix-loop-helix transcription factors Hand1 and Hand2 display dynamic and
spatially restricted expression patterns in the developing heart. Mice that lack Hand2 die at …

Rigorous exploration and dissection of potential actions and effects of long noncoding RNA
(lncRNA) in animals remain challenging. Here using multiple knockout mouse models and …

The HAND2 transcriptional regulator controls cardiac development, and we uncover
additional essential functions in the endothelial to mesenchymal transition (EMT) underlying …