Dysfunction of the autonomic nervous system afflicts most patients with Parkinson disease
and other synucleinopathies such as dementia with Lewy bodies, multiple system atrophy …

The synucleinopathies—Parkinson's disease, dementia with Lewy bodies, multiple system
atrophy, and pure autonomic failure—result from distinct patterns of abnormal α‐synuclein …

Parkinson's disease (PD) and multiple system atrophy (MSA) are disorders associated with
α synuclein‐related neurodegeneration. Nonmotor symptoms are common hallmarks of …

Bladder dysfunction (urinary urgency/frequency) and sexual dysfunction (erectile
dysfunction) are common nonmotor disorders in Parkinson's disease (PD). In contrast to …

Parkinson's disease (PD) is a neurodegenerative disease with a 200 year-long research
history. Our understanding about its clinical phenotype and pathogenesis remains limited …

Opinion statement Autonomic nervous system (ANS) dysfunction is common in Parkinson's
disease (PD), affects 70% to 80% of patients, and causes significant morbidity and …

Pathologic staging systems suggest that autonomic dysfunction may be an early
manifestation of Parkinson's disease and dementia with Lewy bodies. However, direct …

The α-synucleinopathies are a group of neurodegenerative diseases characterized by
abnormal accumulation of insoluble α-synuclein in neurons and glial cells, comprising …

Objective To update evidence‐based medicine recommendations for treating nonmotor
symptoms in Parkinson's disease (PD). Background The International Parkinson and …

Importance Evidence suggests that development of autonomic dysfunction (AutD) may
negatively affect disease course and survival in patients with synucleinopathies. However …