[HTML][HTML] Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism
R Al-Khalidi, C Panicucci, P Cox, N Chira, J Róg… - Acta Neuropathologica …, 2018 - Springer
Duchenne muscular dystrophy (DMD) is the most common inherited muscle disorder that
causes severe disability and death of young men. This disease is characterized by …
causes severe disability and death of young men. This disease is characterized by …
[HTML][HTML] P2RX7 purinoceptor: a therapeutic target for ameliorating the symptoms of duchenne muscular dystrophy
A Sinadinos, CNJ Young, R Al-Khalidi, A Teti… - PLoS …, 2015 - journals.plos.org
Background Duchenne muscular dystrophy (DMD) is the most common inherited muscle
disease, leading to severe disability and death in young men. Death is caused by the …
disease, leading to severe disability and death in young men. Death is caused by the …
Therapeutic approaches for Duchenne muscular dystrophy
TC Roberts, MJA Wood, KE Davies - Nature Reviews Drug Discovery, 2023 - nature.com
Duchenne muscular dystrophy (DMD) is a monogenic muscle-wasting disorder and a
priority candidate for molecular and cellular therapeutics. Although rare, it is the most …
priority candidate for molecular and cellular therapeutics. Although rare, it is the most …
Dystrophin: The dead calm of a dogma
DC Górecki - Rare Diseases, 2016 - Taylor & Francis
Duchenne muscular dystrophy (DMD) is the most common inherited muscle disease leading
to severe disability and death of young men. Current interventions are palliative as no …
to severe disability and death of young men. Current interventions are palliative as no …
Mammalian models of Duchenne Muscular Dystrophy: pathological characteristics and therapeutic applications
A Nakamura, S Takeda - BioMed Research International, 2011 - Wiley Online Library
Duchenne muscular dystrophy (DMD) is a devastating X‐linked muscle disorder
characterized by muscle wasting which is caused by mutations in the DMD gene. The DMD …
characterized by muscle wasting which is caused by mutations in the DMD gene. The DMD …
Duchenne muscular dystrophy: pathogenesis and promising therapies
M Chang, Y Cai, Z Gao, X Chen, B Liu, C Zhang… - Journal of …, 2023 - Springer
Duchenne muscular dystrophy (DMD) is a severe, progressive, muscle-wasting disease,
characterized by progressive deterioration of skeletal muscle that causes rapid loss of …
characterized by progressive deterioration of skeletal muscle that causes rapid loss of …
Murine models of Duchenne muscular dystrophy: is there a best model?
K Swiderski, GS Lynch - American Journal of Physiology …, 2021 - journals.physiology.org
Duchenne muscular dystrophy (DMD) is a debilitating X-linked recessive skeletal muscle-
wasting disorder affecting 1 in 3,500–6,000 live-born males. Despite mutations in the dmd …
wasting disorder affecting 1 in 3,500–6,000 live-born males. Despite mutations in the dmd …
Impending therapies for Duchenne muscular dystrophy
TA Partridge - Current opinion in neurology, 2011 - journals.lww.com
Although genetic and cell-mediated approaches are currently showing genuine promise in
preclinical and clinical trials, there remains considerable interest in the development of …
preclinical and clinical trials, there remains considerable interest in the development of …
Pharmacologic management of Duchenne muscular dystrophy: target identification and preclinical trials
Duchenne muscular dystrophy (DMD) is an X-linked human disorder in which absence of
the protein dystrophin causes degeneration of skeletal and cardiac muscle. For the sake of …
the protein dystrophin causes degeneration of skeletal and cardiac muscle. For the sake of …
Evolving therapeutic options for the treatment of duchenne muscular dystrophy
ES D'Ambrosio, JR Mendell - Neurotherapeutics, 2023 - Elsevier
Duchenne muscular dystrophy (DMD) is the most common childhood form of muscular
dystrophy. It is caused by mutations in the DMD gene, leading to reduced or absent …
dystrophy. It is caused by mutations in the DMD gene, leading to reduced or absent …