SARS‐CoV‐2 papain‐like protease: structure, function and inhibition
Emerging variants of SARS‐CoV‐2 and potential novel epidemic coronaviruses underline
the importance of investigating various viral proteins as potential drug targets. The papain …
the importance of investigating various viral proteins as potential drug targets. The papain …
[HTML][HTML] Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease
V Srinivasan, H Brognaro, PR Prabhu… - Communications …, 2022 - nature.com
Abstract SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the
cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the …
cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the …
Discovery of novel papain-like protease inhibitors for potential treatment of COVID-19
F Hersi, A Sebastian, H Tarazi, V Srinivasulu… - European Journal of …, 2023 - Elsevier
The recent emergence of different SARS-CoV-2 variants creates an urgent need to develop
more effective therapeutic agents to prevent COVID-19 outbreaks. Among SARS-CoV-2 …
more effective therapeutic agents to prevent COVID-19 outbreaks. Among SARS-CoV-2 …
Structure-based design of SARS-CoV-2 papain-like protease inhibitors
The COVID-19 pandemic is caused by SARS-CoV-2, an RNA virus with high transmissibility
and mutation rate. Given the paucity of orally bioavailable antiviral drugs to combat SARS …
and mutation rate. Given the paucity of orally bioavailable antiviral drugs to combat SARS …
[HTML][HTML] Potential inhibitors targeting papain-like protease of SARS-CoV-2: two birds with one stone
H Jiang, P Yang, J Zhang - Frontiers in chemistry, 2022 - frontiersin.org
Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), the pathogen of the
Coronavirus disease-19 (COVID-19), is still devastating the world causing significant chaos …
Coronavirus disease-19 (COVID-19), is still devastating the world causing significant chaos …
[HTML][HTML] Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2
H Shan, J Liu, J Shen, J Dai, G Xu, K Lu, C Han… - Cell chemical …, 2021 - cell.com
The COVID-19 pandemic has been disastrous to society and effective drugs are urgently
needed. The papain-like protease domain (PLpro) of SARS-CoV-2 (SCoV2) is …
needed. The papain-like protease domain (PLpro) of SARS-CoV-2 (SCoV2) is …
[HTML][HTML] The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery
SARS-CoV-2 is the pathogen responsible for the COVID-19 pandemic. The SARS-CoV-2
papain-like cysteine protease (PLpro) has been implicated in playing important roles in virus …
papain-like cysteine protease (PLpro) has been implicated in playing important roles in virus …
Targeting SARS‐CoV‐2 viral proteases as a therapeutic strategy to treat COVID‐19
The 21st century has witnessed three outbreaks of coronavirus (CoVs) infections caused by
severe acute respiratory syndrome (SARS)‐CoV, Middle East respiratory syndrome (MERS) …
severe acute respiratory syndrome (SARS)‐CoV, Middle East respiratory syndrome (MERS) …
Structure‐activity relationships of benzamides and isoindolines designed as SARS‐CoV protease inhibitors effective against SARS‐CoV‐2
Inhibition of coronavirus (CoV)‐encoded papain‐like cysteine proteases (PLpro) represents
an attractive strategy to treat infections by these important human pathogens. Herein we …
an attractive strategy to treat infections by these important human pathogens. Herein we …
[HTML][HTML] Crystal structure of SARS-CoV-2 papain-like protease
X Gao, B Qin, P Chen, K Zhu, P Hou, JA Wojdyla… - … Pharmaceutica Sinica B, 2021 - Elsevier
The pandemic of coronavirus disease 2019 (COVID-19) is changing the world like never
before. This crisis is unlikely contained in the absence of effective therapeutics or vaccine …
before. This crisis is unlikely contained in the absence of effective therapeutics or vaccine …